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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The mammalian olfactory bulb (OB) has a vast population of dopamine (DA) neurons, whose function is to increase odor discrimination through mostly inhibitory synaptic mechanisms. However, it is not well understood whether there is more...
This manuscript uses sound localization circuitry in the chick brainstem to examine the balance of inhibitory and excitatory neurotransmission maintained by neural circuits. This is a particular challenge in sensory systems, like the...
Shape represents a complex and rich source of biological information that is fundamentally linked to underlying mechanisms and functions. Many fields of biology employ mathematical tools for the statistical analysis of shape variation....
There is a well-established relationship between the olfactory and the endocrine systems. At the center of this relationship sits the olfactory bulb, which acts as a relay station for the sense of smell. In fact, neurons in the olfactory...
Microfiltration is one of the most efficient filtration techniques used to remove pathogenic protozoa, bacteria, and other colloidal matter from feed water. During the filtration process these pollutants accumulate on the filter surface...
The cerebral cortex is a thin folded sheet of neural tissue forming the outmost layer of the cerebrum (brain). Several biological hypotheses have suggested dierent mechanisms involved the development of its folding pattern into sulci ...
Vortex waves are striking spatial-temporal patterns and observed in diverse systems, such as active galaxies, catalytic reactions, and even biological systems. In the heart, vortex patterns of electrical waves are linked to ventricular...
Animals must eat to attain essential nutrients and energy for survival. Diet -- the types and quantities of food consumed -- is clearly tied to the overall health of humans and other animals. So, too, is the way in which those foods are...
While modern medicine has made enormous strides in improving patient care, treatment outcomes, and overall quality of life. It has become increasingly more clear that collaborative and highly interdisciplinary research is necessary to...
Speech production is a learned behavior requiring sensorimotor integration. For humans and other species that produce learned vocalizations, an individual must be exposed to sufficient auditory input, typically early in development. Then...
Improving the Accuracy of 3D Chromosome Structure Inference and Analyzing the Organization of Genome in Early Embryogenesis Using Single Cell Hi-C Data
This dissertation summarizes my graduate work on the structure and organization of mouse genome during preimplantation development. My research is divided into three different areas, which I will discuss in turn. To begin, I will discuss...
In male zebra finches, the song learning process can be divided in to two distinct-but-overlapping stages: sensory, and sensorimotor, which are scaffolded by concurrent changes in the brain. In the male song network, dual premotor...
My dissertation focuses on how the brain encodes a learned motor sequence. I look at the encoding of birdsong in the zebra finch (Taeniopygia guttata) to understand the mechanisms that underlie motor encoding. Juvenile zebra finches...
Understanding the genetic basis of phenotypic variation in organisms is a central problem in developmental and evolutionary biology. In plant science, to gain insights on such problems as how plants respond to environmental changes and...
While the immune system is extraordinarily complex and powerful, and medical advancements are more spectacular than ever, in recent history we have seen the unfortunate failure of both processes (immune system and drugs) in the...
Prostate cancer is currently a major pubic health issue due to the fact that it is the second most common cancer in men with an estimated 174, 650 new cases diagnosed in 2019. While prostate cancer has a survival rate of nearly 100% for...
In this Dissertation, I report parallel processing in the avian vocal premotor nucleus HVC. First, I review historical ideas and recent evidence about the function of HVC. HVC has historically been viewed as a distributed network, and it...
A Novel Model for Precipitation Reactions in Microfluidic Devices or, a Unified Framework for Coupling Phase-Change Chemistry and Fluid-Structure Interaction in Low Reynolds Number Flows
Chemical processes within flows are ubiquitous. There exists an important class of reactions that result in a phase change from liquid to solid: precipitation reactions. Inspired by recent microfluidic experiments, this dissertation...
The process of learning well-coordinated motor sequences is an essential aspect of human behavior. Learning to speak, play an instrument, or swing a baseball bat requires the brain to encode a very specific sequence of motor activity. It...
A finite dimensional amplitude equation model of 2-dimensional double-diffusive convection near a quadruple-zero (codimension 4) bifurcation point is derived using center manifold reduction. The derivation employs small perturbation...
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