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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Small nucleolar RNAs (snoRNAs) are localized in the nucleolus as small ribonucleoprotein particle (snoRNP) that are RNA-protein complexes and catalyze site specific modifications on the ribosomal RNA. When compared to many protein...
The 26S proteasome is the largest and most complicated chambered protease known. It is responsible for regulated degradation of proteins within all eukaryotic cells, and is essential for maintaining protein homeostasis. Disruptions to...
IdeR is an iron-dependent repressor protein, one of the essential proteins found in Mycobacterium tuberculosis. IdeR is a homologue of the diphtheria toxin repressor (DtxR). IdeR controls iron acquisition and storage, moreover it binds...
The relationship between protein structure and the specificity of substrate oxidation remains a key problem in the study of the lipoxygenase enzyme family. Polyunsaturated lipid substrates reach the non-heme iron contained within the...
Muscle generates force through the interaction between myosin cross-bridges and actin filaments. This study is part of a research project that aims to understand the molecular mechanism of force production through direct visualization of...
Allergic diseases are a heterogeneous group of type I IgE-mediated hypersensitivity reactions affecting more than 25% of the world's population of developed countries becoming a major clinical and public health issue. According to the...
Molecular interactions form the basis for all cellular functions ranging from nutrient sequestration to signal transduction. While specific interactions have been extensively studied in the biomolecular context, the importance of non...
Unraveling the detailed molecular mechanisms involved in muscle contraction is a prerequisite for understanding the molecular basis of muscular disorders. Troponin (Tn) plays a key role in muscle regulation, and it is composed of three...
The Michael addition of lithium enolates to ฮฑ, ฮฒ unsaturated esters is considered to be one of the powerful and widely used C-C bond forming methods in organic synthesis. We investigated the Michael addition of lithium propionate enolates...
Lipid oxidation pathways and nitric oxide signaling pathways are interrelating pathways with significance both separately and in conjunction (references 1-2). Lipid oxygenating pathways involve the formation of hydroperoxides, alkanes, ...
Cell adhesion assemblies occur at sites where cells either contact each other or components related to the extracellular matrix. They provide the structural integrity needed to support nonmigrating cells via a host of transmembraneous...
Polyelectrolyte multilayers are made by the alternating adsorption of oppositely charged polyelectrolytes. Thin films with bioactive or biospecific properties may be designed and produced using an extraordinary range of multicomposites...
Cardiomyopathies are a heterogenous group of myocardial disorders that are frequently associated with a genetic etiology. The cardiac/slow skeletal troponin C gene (TNNC1) encodes a sarcomeric protein (TNNC1) that has a central role in...
The Iron-dependent Regulator (IdeR) is a 230-amino acid transcriptional repressor that regulates iron homeostasis, oxidative stress response and virulence in Mycobacterium tuberculosis. The importance of IdeR for mycobacterial metabolism...
Petroleomics: Applications in the Fingerprinting of the Acidic and Basic Crude Oil Components Detected by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
We have previously demonstrated the ability of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) to resolve and identify the polar species found in all petroleum distillates. The...
Diphtheria toxin repressor protein (DtxR) is a 226 amino acid protein that regulates the genes for iron uptake in Corynebacterium diphtheria and also regulates the Diphtheria toxin production. The known functions of this protein include...
The centrosome, comprised of a pair of centrioles, is the best-studied microtubule-organizing center (MTOC). However, after utilizing the centrosome to organize the mitotic spindle during cell division, differentiated cells will often...
Arginine kinase buffers cellular ATP levels by catalyzing reversible phosphoryl transfer between ATP and arginine. A conserved cysteine has long been thought important in catalysis. Here, cysteine 271 of horseshoe crab arginine kinase...
The M2 proton channel from Influenza A is an established drug target, with multiple functions during the viral lifecycle. Amino acid mutations, in the residues lining the channel pore, have rendered M2 resistant to previously licensed...
Despite the existence of structures of substrate-bound and substrate-free forms of two highly specific members of the family of phosphagen (guanidino) kinases, namely arginine and creatine kinase, the full determination of the structural...
Synthesis and degradation of proteins in a cell must be carefully balanced to ensure organismal health. The 26S proteasome is a large protein complex that carries out most regulated protein degradation in eukaryotes. The assembly, ...
Monoclonal antibody (mAb) A20 is the best characterized AAV2 neutralizing mAb [18, 116, 165]. Large quantities of the mAb A20 were obtained from hybridomas cell culture, and A20 Fab fragments were produced and purified by standard...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
