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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Solution-Phase Hydrogen/Deuterium Exchnage Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Technique Development and Application to Muscle Biochemistry
Proteins are vital macromolecules of every living cell. They undertake a variety of tasks that are essential for life. Most proteins function in assemblies rather than individually. Protein function is strongly correlated to structure...
Genetic animal models have become an increasingly useful tool in addressing pathophysiological changes in neuropsychiatric disorders at the molecular, synaptic and circuitry levels. Previous genetic and postmortem studies have identified...
Progress in nanotechnology is trending towards applications which require the integration of soft (organic or biological) and hard (semiconductor or metallic) materials. Many applications for functional nanomaterials are currently being...
The Standard Model (SM) of particle physics offers the most complete quantum description of the known universe to date, however is unable to address some still unanswered questions. Supersymmetry (SUSY) is a theory which proposes partner...
In Chapter I, the photochemistry of enediynes is reviewed. Photo-Bergman cyclization, C1-C5 photocyclization and other photochemical reactions of alkynes in the enediyne moiety are discussed. DNA cleavage by photochemically activated...
Older adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents....
The Effects of Twelve Weeks of Whole-Body Vibration Training and Low-Intensity Resistance Exercise Training on Arterial Function, Muscle Strength, and Physical Performance in Dynapenic Postmenopausal Women
Cardiovascular disease (CVD) remains the leading cause of death in the modern world, markedly in postmenopausal women. Increased arterial stiffness, measured as increased pulse wave velocity (PWV), and endothelial dysfunction are large...
The presence of misbranding and undeclared allergenic residues was the number one cause of food recalls in the United States, between 2012 to 2016. In this study, parvalbumin was used as a model to study the matrix effect on...
Cardiovascular disease (CVD) is a major public health challenge and the leading cause of death and disability worldwide. Atherosclerosis, a primary underlying cause of CVD, results from oxidative stress, chronic inflammation, and excess...
PURPOSE: Diving operations may require personnel to be immersed for extended periods while breathing compressed air or 100% O2. The main objective of this study was to investigate the physiological effects of single and repetitive diving...
Scientists have used computers to model a plethora of systems since the rise of the computer age. The most common use of modeling is to analyze an existing system. With a complete model of an existing system the parameters can be changed...
Muscle atrophy decreases physical function and overall health. Increased glucocorticoid production and/or use of prescription glucocorticoids can result in a myopathy that presents with significant muscle atrophy and weakness....
Ovariectomized (ovx) rats gain excess body weight (BW) even when they are pair-fed to sham animals. This higher BW, contrary to common belief, does not result in higher bone mineral density. The purpose of the present study was to...
This dissertation describes the development of copper(II)-mediated azide-alkyne cycloaddition reactions using chelating azides. The first chapter provides an introduction to the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)...
Purpose: The purpose of this study was to investigate whether acute exercise will affect serum hepcidin levels and iron status in active women. Additionally, two different exercise durations were compared to determine if there is a...
Hypogonadism contributes to limb skeletal muscle atrophy by increasing rates of muscle protein breakdown. Androgen depletion increases markers of the autophagy-mediated protein breakdown pathway that persist throughout the diurnal cycle....
Possibly affecting at least 1.5 million Americans today, cardiomyopathy greatly contributes to the reign of heart disease as the number one killer in the United States. Consisting of four main disease manifestations (hypertrophic, ...
Cardiomyopathies are a heterogenous group of myocardial disorders that are frequently associated with a genetic etiology. The cardiac/slow skeletal troponin C gene (TNNC1) encodes a sarcomeric protein (TNNC1) that has a central role in...
The work in this dissertation presents methods for study of glucose stimulated insulin secretion as well as other hormones involved in glucose homeostasis. A microfluidic system was developed to investigate the entrainment of insulin...
The use of targeted-dye-labeling to probe environs within larger microenvironments is a powerful tool to elucidate the structure and function of specific components in materials. Combining site-specific dye-labeling with optical...
In Chapter I, hybrid agents which combine potent DNA-photocleavers with tunable amino acids or small peptides are reviewed. These molecules were designed to improve selectivity of Nature's most potent class of antibiotics towards cancer...
Temporal lobe epilepsy (TLE) is the commonest of adult epilepsies, often refractory to antiepileptic medications, whose prevention and treatment rely on understanding basic pathophysiological mechanisms in interlinked structures of the...
Pre-sleep protein has been shown to improve overnight muscle protein synthesis, muscle size and strength, and muscle recovery. However, all pre-sleep protein studies to date have utilized dairy-based protein sources. There is currently a...
The use of gas chromatography-mass spectrometry to measure the relative pool size and 13C-enrichment of a broad range of intracellular metabolites to monitor changes in the metabolome of mammalian cells is described. The typical workflow...
Early afterdepolarizations (EADs) are pathological voltage fluctuations that can occur during an action potential in cardiac cells and are a potent source of potentially fatal arrhythmia. As such, there are long-running experimental and...
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