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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Molecules containing the phosphate (O—PO32-) moiety are ubiquitous in biochemistry. Phosphoryl transfer reactions that break and form the O—P phosphoryl bond are central to biological processes as diverse as energy metabolism and signal...
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has ultrahigh mass resolving power (m/Dm50% >300, 000) and high mass accuracy (300, 000) and high mass accuracy (ppm), which enables separation and identification of...
Most biomolecular NMR experiments rely on 1H detection because it offers high sensitivity, but 1H NMR experiments are limited by the chemical shift dispersion of 1H which presents significant challenges for accurate peak identification...
Targeting the Kv1.3 Ion Channel with Peptide Inhibitors and Nanoparticle Bioconjugates: Neuromodulation of the Olfactory Bulb and Its Influence on Whole-Body Metabolism
Electrical signaling in the olfactory bulb (OB) is modulated by changes in metabolic state. The voltage-gated potassium channel, Kv1.3, makes up 60 - 80% of the outward current flow in mitral cells (MCs), the primary projection neurons...
Adeno-associated virus type-2 (AAV-2) is a leading candidate vector for gene therapy. My PhD is a part of the ongoing research project towards the long-term goals of engineering AAV to evade immune neutralization when repeated doses are...
Diphtheria toxin repressor (DtxR) is an Fe(II)-activated transcriptional regulator of iron homeostatic and virulence genes in Corynebacterium diphtheriae and co-regulates expression of diphtheria toxin gene. DtxR contains an N-terminal...
Atomic structures of biological systems can be obtained by several experimental methods, X-ray crystallography being one of the most widely used. Crystallography can provide a high resolution visualization (better than 1 A), but for...
In aqueous solution, solute conformational transitions are governed by intimate interplays of the fluctuations of solute–solute, solute–water, and water–water interactions. To more effectively sample conformational transitions in aqueous...
Atomic structure determination of membrane proteins is an important problem. Because of the difficulties in crystallization and traditional NMR techniques using membrane proteins, other experimental methods are being developed and...
Voltage-gated potassium channels (Kv channels) play a vital roll in cellular excitability and neuronal communication by catalyzing the translocation of potassium ions across cellular membranes. After synthesis occurs in the endoplasmic...
The classical Frenet frame is a moving frame on a smooth curve. Connecting a sequence of points in space by line segments makes a discrete curve. The reference frame consisting of tangent, normal and binormal vectors at each point is...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
