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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Understanding the ultimate and proximate mechanisms of spadefoot tadpole developmental polyphenism is the first step in gaining a mechanistic and evolutionary understanding of the factors responsible for the control and evolution of...
Budding yeast, Saccharomyces cerevisiae, has a unique cell cycle. During its S-phase, DNA replication occurs, but spindle formation and chromosome-microtubule attachment also take place. Thus, how to couple spindle formation and...
Alcohol abuse is more prevalent in populations in which sleep deprivation is more common including shift workers and older individuals. While much research has investigated the impact of alcohol use and abuse on sleep quality, little is...
Among flowering plants, floral form is inherently linked to reproductive success and is therefore a key element in the evolution of angiosperm lineages. Variations in floral form and associated mating systems have demonstrated that...
In Plasmodium falciparum-infected children, the relationships between blood cell histopathology, blood plasma components, development of immunocompetence, and disease severity remain poorly understood. This investigation relates levels...
BCL6, a protooncogene, is most commonly involved in diffuse large cell lymphomas (DLCL) which is the most common form of non-Hodgkin lymphoma. BCL6 recruits a number of transcriptional corepressors including BCL6 corepressor (BCoR) to...
Gene expression and regulation in early vertebrate development has been examined in Xenopus laevis, a model organism for embryonic developmental biology. Two related projects were carried out and they are described in separate chapters....
A great challenge that biology faces is in integrating phenomena from different scales. On the micro scale of the spectrum, we can measure subcellular processes, like gene expression and regulation. On the macro scale, we can measure...
Olfaction allows vertebrates to sense their chemical environment, and plays an important role in feeding behavior, reproduction, memory and learning. The first portion of the dissertation examined the signal transduction cascade in the...
Electron microscopy is an important technique for observing macromolecular structures, such as DNA and viruses, which would be too small to see under light microscopy. This type of microscopy utilizes electrons as its illumination source...
Biocompatible coatings are often used to improve fixation between implants and tissues. Polyelectrolyte multilayer (PEMU) coatings built layer by layer with alternating pairs of polyelectrolytes can be tuned to improve cell interactions...
X chromosome inactivation (XCI), the mammalian form of dosage compensation, is a canonical example of epigenetic regulation and involves the transcriptional repression of nearly an entire chromosome (Xi) while preserving the...
During the age of non-avian dinosaurs, ancestors of present-day mammals were likely small insectivores, relegated to nocturnal and subterranean niches. This nocturnal "bottle-neck" is postulated as a driving force of numerous...
Short Hairpin RNAs Delivered by Lentiviral Vector Transduction Trigger RIG-I-Mediated IFN Activation and Isolation of HCV with Enhanced Kinetics and Viral Assembly
Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, ...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
