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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
My research is designed to test the hypothesis that a single nucleotide polymorphism (SNPs) in the non-coding region of the GCH1 gene suppresses GCH1 mRNA translation and generates a novel peptide, and that both of these phenomena...
Extracellular vesicles (EVs) are membrane-encapsulated structures released by cells which carry signaling factors, proteins and microRNAs that mediate intercellular communication. Accumulating evidence supports an important role of EVs...
Uncorrected defects in the kinetochore-microtubule interaction lead to chromosome mis-segregation and aneuploidy, a phenotype found in over 90% of cancers. Therefore cells have developed different strategies to ensure chromosome bipolar...
Autism spectrum disorder (ASD) embodies a spectrum of complex, pervasive, and heterogeneous neurodevelopmental disorders. There is not one single identified cause, but is instead composed of dynamically diverse etiologies and...
Extracellular vesicles (EVs) are a heterogeneous population of membrane-bound nanoparticles that are essential mediators of cell-to-cell communication. They package diverse cargo that includes proteins, lipids, RNA, and DNA. EVs are...
Alzheimer's disease (AD) currently underlies dementia for tens of millions of people worldwide, and its occurrence is set to double in the next 20 years. The currently approved drugs for treating AD only marginally ameliorate cognitive...
Maintenance of the integrity of the genome is vital to survival and the small non-histone protein Heterochromatin protein 1 (HP1) plays an important role in the process. Here we demonstrate two roles for HP1 in regulating transcription...
Protein phosphorylation ' a reversible covalent process ' has evolved as one of the major posttranslational modifications that targets numerous transcription factors. Apoptosis (programmed cell death) is an irreversible intrinsic...
Liver fibrosis is the common end stage of all chronic liver diseases, such as chronic viral hepatitis, alcoholism, nonalcoholic fatty liver disease, autoimmune hepatitis, alpha 1 anti-trypsin deficiency and some rare metabolic diseases....
Accurate replication of DNA once and only once per cell cycle is an essential process for all living organisms. Despite many studies aimed at understanding this phenomenon, no mechanism describing where and when replication initiates in...
The faithful maintenance of structure and function of chromatin is crucial for maintaining genomic stability. In proliferating cells, nucleosome assembly occurs largely during S-phase with a strict coordination between DNA and histone...
When cells encounter DNA replication stress, the S-phase checkpoint is activated to facilitate cell cycle arrest and DNA repair. An important aspect of the checkpoint is the transcriptional response, but the details governing this...
The mechanisms underlying the gestational and circadian timing of parturition in humans are not fully understood. Studies of the timing of initiation of spontaneous labor show a peak between 2400 and 0500. This peak in labor onset...
Yin Yang 1 (YY1) is a multifunctional transcription factor that can activate or repress transcription depending on the promotor and/or the co-factors recruited. YY1 is phosphorylated in various signaling pathways and is critical for...
Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. ZIKV is part of the genus flavivirus, a class of positive(+)- sense single-stranded RNA viruses. Flavivirus...
Investigation of the Effects of G9a Knockout on Subnuclear Localization and Replication Timing of G9a Repressed Genes When Integrated into an Early Replicating Region
G9a is a histone methyltransferase that is responsible for dimethylation of histone 3 lysine 9 (H3K9me2) this chromatin marker is typically associated with transcriptional silencing. Following conditional knockout of G9a in mouse...
Stress is a ubiquitous aspect of everyday life. As such, there exists a great deal of variability in the individual response to stress, particularly as a functional cause of depression. The aim of this dissertation is to investigate the...
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects. Bipolar kinetochore attachment is required for SAC silencing which allows for anaphase onset and the release of the phosphatase, ...
The pancreas is an organ located in the abdomen. It is made up of exocrine cells and endocrine cells. In particular, the endocrine cells include hormone-producing cells that form clusters within the pancreas, called islets of Langerhans....
The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding. Misfolded proteins are aggregation prone and protein aggregation are associated with many human diseases, ...
Tight regulation of the cell cycle is essential to maintain genome integrity. Errors at any stage during cell cycle, including replication, chromosome segregation, and mitotic exit, can lead to genome instability, which has been shown to...
In mammalian cells, cyclin dependent kinase (CDK) is subjected to negative regulation by a conserved kinase, Wee1. In budding yeast, S. cerevisiae, Swe1 kinase, the Wee1 homologue, phosphorylates and inactivates Cdk1 associated with...
Our DNA is under continuous stress by endogenous and exogenous attacks such as genotoxic chemicals, ionizing radiation, and metabolic products. DNA damage is extremely detrimental, even a single unrepaired damage is sufficient to kill a...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
