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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
This thesis analyzes the structure and function of enzymes involved in the biosynthesis of the tetrapyrrole cofactor, siroheme, a critical cofactor used in sulfur and nitrogen metabolism in plants, bacteria, and some archaea. The...
Protein residue ionization often plays a vital role in protein function, such as enzyme catalysis and pH-dependent structural changes. Inadequate conformational and protonation state sampling in molecular dynamics (MD) simulations has...
Structural biology has been successful in the characterization of soluble protein, which has given insight in the inner working of several thousands of proteins. However, structural characterization of proteins has been limited in two...
The evolutionary arms race for survival against phages and other mobile genetic elements has produced a wide repertoire of defensive strategies in prokaryotes. CRISPR (Clustered, regularly-interspaced, short palindromic repeats) systems...
We describe a cryo-electron microscopy 3D image reconstruction of relaxed myosin II-containing thick filaments from the flight muscle of the giant waterbug Lethocerus indicus. The relaxed thick filament structure is a key element of...
A major focus of scientific research is to understand biological phenomena and to explain our basic observations of life, however these phenomena have an underlying basis and are the result of many biophysical processes. The study of...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
