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Considerable attention has recently been given to the preparation of the ciguatoxins, the major group of toxins implicated with the onset of ciguatera fish poisoning (CFP) – a seafood-borne illness associated with the consumption of reef...
Two independent topics are covered in this thesis. The first project covers the development of a new hydroxyl protecting group: para-siletanylbenzyl (PSB). The para-siletanylbenzyl (PSB) ether is electronically similar to the benzyl...
The Michael addition of lithium enolates to α, β unsaturated esters is considered to be one of the powerful and widely used C-C bond forming methods in organic synthesis. We investigated the Michael addition of lithium propionate enolates...
Substantial attention has been given to the synthesis of Taxol due to its cytotoxic activity towards certain cancers. Because of Taxol's structural complexity, total synthesis of the molecule cannot provide a commercial supply. Its...
Roseophilin is an ansa-bridged potent cytotoxic compound that has generated continual interest from synthetic chemists since its discovery in 1992. As a synthetic target, roseophilin's most difficult challenge is the construction of the...
Rv3004 and Rv1861 are membrane proteins from Mycobacterium tuberculosis. Rv3004 is a 112 amino acid protein with one predicted transmembrane helix. Rv1861 is a 101 amino acid protein with three predicted transmembrane helices. Both...
This dissertation is composed of two independent research projects. The first part describes the synthesis and reactivity of siletanylmethyllithium, and includes a thorough review of the chemistry of siletanes. Siletanylmethyllithium was...
The total synthesis towards 1-deoxytaxol analogs is described. The synthesis relies on new methods to install the C3-C4 bond and to achieve the tricyclic taxane ring skeleton. The first section describes the formation of the C3-C4 bond...
The total synthesis of taxol has been attempted and successfully completed by many well known chemists. However, the access to analogs is still limited, and the complex structure of the ABC skeleton of taxol does not allow much...
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