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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Box C/D snoRNPs catylze the specific 2'O-methylation of rRNA in important regions the ribosome, although the role of the modifications is unclear. Eukaryotic box C/D snoRNPs consists of a box C/D RNA and four proteins, Fibrillarin, Nop56...
Small nucleolar RNAs (snoRNAs) are localized in the nucleolus as small ribonucleoprotein particle (snoRNP) that are RNA-protein complexes and catalyze site specific modifications on the ribosomal RNA. When compared to many protein...
All functional RNAs contain post-transcriptionally modified nucleotides. 2'-O-ribose methylation and pseudouridylation are the two major types of modifications, which occur by box C/D and box H/ACA ribonucleoprotein (RNP) complexes, ...
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) offer an adaptive immune system that protects bacteria and archaea from nucleic acid invaders through an RNA-mediated nucleic acid cleavage mechanism. Our knowledge of...
Box H/ACA ribonucleoprotein particle (RNP), an RNA-guided RNA modification enzyme, is comprised of four conserved proteins (Cbf5, Nop10, Gar1 and L7Ae) and one guide RNA. This complex recognizes the substrates by the guide RNA and...
In eukaryotes and archaea 5-25% of transfer RNA (tRNA) precursors contain intervening sequences, or introns, that interrupt the molecules' functional regions. Because functional tRNA molecules are necessary for protein synthesis, ...
As an RNA-guided RNA modification enzyme, the box H/ACA RNP recruits the guide RNA to recognize the substrate RNA, whereas the protein partners carry out the catalysis. Most intriguingly, box H/ACA RNPs share the same four conserved...
The landscape of RNA biology and its derived biotechnology is continually evolving, and one of the most groundbreaking has been the discovery and subsequent characterization of Clustered Regularly Interspaced Short Palindromic Repeats ...
Eukaryotic ribosome is maturated through a complicated process orchestrated by a large network of biogenesis factors. Small nucleolar ribonucleoprotein particles (snoRNPs) contribute to ribosome biogenesis by processing and chemically...
The evolutionary arms race for survival against phages and other mobile genetic elements has produced a wide repertoire of defensive strategies in prokaryotes. CRISPR (Clustered, regularly-interspaced, short palindromic repeats) systems...
Biogenesis of eukaryotic ribosomes is a complicated process that needs to be highly coordinated and tightly regulated. The small nucleolar ribonucleoprotein particles (snoRNPs) mediate the first step of ribosome biogenesis by carrying...
The Clustered Regularly Interspaced Short Palindromic Repeat loci found in most archaea and some bacteria contain DNA sequences (spacers) that originate from genetic invaders like viruses, transposons, and plasmids. The CRISPR clusters...
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) interference is a newly discovered small-RNA based immune system used by bacteria and archaea. One of the essential steps in this interference is to process long CRISPR...
The RNA splicing and processing endonuclease from Nanoarchaeum equitans (NEQ) belongs to the recently identified (ab)2 family of splicing endonucleases that require two different subunits for splicing activity. N. Equitans splicing...
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) interference is a newly discovered small-RNA based immune system used by bacteria and archaea. One of the essential steps in this interference is to process long CRISPR...
Ribosomes are giant RNA-protein complexes responsible for translating the information encoded by the genome to create the proteome in all kingdoms of life. In budding yeast, the mature cytoplasmic 80S ribosome consists of 79 ribosomal...
The Eukaryotic cells employ a sophisticated process to generate properly assembledribosomes. This intricate process commences in the nucleolus through the transcription of a singular 35S ribosomal RNA precursor (pre-rRNA), encompassing...
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