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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Limiting undesired interactions of proteins with surfaces is a vital task for implementation of many technologies that require direct exposure to protein media. This includes sensors, single molecule spectroscopy studies, and...
Microfluidics is the field of study involving the manipulation of fluid in devices with micron scale length dimensions and, typically, nano- to picoliter fluid volumes. Miniaturization gives rise to specific advantages in the field of...
Water soluble polyelectrolytes have gained great interest for their low toxicity and wide applications. Oppositely charged polyelectrolytes (polycations and polyanions) can produce thin multilayers through a layer-by-layer technique and...
The age of big data has re-invited much interest in dimension reduction. How to cope with high-dimensional data remains a difficult problem in statistical learning. In this study, we consider the task of dimension reduction---projecting...
This dissertation discloses the work of two research projects: the synthesis and study of twisted cycloalkynes for click chemistry and traceless directing groups used in radical cascade cyclizations. The structural design of the...
The trigeminal subnucleus caudalis (Vc), which has been designated as the "medullary dorsal horn"- analogous to the spinal dorsal horn (DH), relays noxious input from the orofacial region to higher brain centers. Recent work in our lab...
Controlling cell fate via mechanical properties of the culture substrates provides an important tool for biomedical applications. Thin films of polyelectrolyte multilayers (PEMUs) have been used as substrates for cell culture due to...
Hepatitis C virus (HCV) has emerged as a major cause of human liver disease, with ~3% of the world population persistently infected with and more than one million new cases of infection reported annually. In most cases, HCV escapes the...
Tissue integrity and homeostasis are accomplished through strict spatial and temporal regulation of cell growth and proliferation during development. A derailment of such balance may lead to tumorigenesis. Various signaling pathways have...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.