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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The 26S proteasome is the largest and most complicated chambered protease known. It is responsible for regulated degradation of proteins within all eukaryotic cells, and is essential for maintaining protein homeostasis. Disruptions to...
The follicular epithelium (FE) of the Drosophila egg chamber is an excellent model system to study cell-cycle regulation, cell differentiation and cell migration in development. During oogenesis, follicle cells sequentially undergo three...
Accurate chromosome segregation is vital to maintain genomic integrity. Chromosome missegregation, or aneuploidy, contributes to cancer development and conditions like down syndrome (Trisomy 21). Chromosomes are attached to microtubules...
Extracellular vesicles (EVs) are membrane enclosed vesicles released from cells that act as mediators of intercellular communication and are involved in normal physiological processes as well as pathological conditions. EVs can transfer...
Understanding the neural and genetic basis of complex behaviors is a major outstanding question in neurobiology. The fruit fly, Drosophila melanogaster, displays innate, complex reproductive behaviors. These behaviors are regulated by...
Fibroblast growth factor-1 (FGF-1) is an angiogenic factor with therapeutic potential for the treatment of ischemic disease. FGF-1 has low intrinsic thermostability and is characteristically formulated with heparin as a stabilizing agent...
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects. Bipolar kinetochore attachment is required for SAC silencing which allows for anaphase onset and the release of the phosphatase, ...
The pancreas is an organ located in the abdomen. It is made up of exocrine cells and endocrine cells. In particular, the endocrine cells include hormone-producing cells that form clusters within the pancreas, called islets of Langerhans....
Traumatic Brain Injury (TBI) gives rise to a progressive disease state that results in many adverse and long-term neurological consequences, including deficits in learning and memory, development of major depressive disorder, and...
Maintaining the balance of protein synthesis and degradation is essential for efficient proteostasis and organismal health. The 26S proteasome is a large, multisubunit proteolytic complex that functions as the primary mechanism for...
The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding. Misfolded proteins are aggregation prone and protein aggregation are associated with many human diseases, ...
One of the core pathogenic mechanisms for schizophrenia is believed to be dysfunction in glutamatergic synaptic transmissions, particularly hypofunction of N-methyl D-aspartate receptors (NMDARs). In addition, previous genetic and...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
