Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Solution-Phase Hydrogen/Deuterium Exchnage Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Technique Development and Application to Muscle Biochemistry
Proteins are vital macromolecules of every living cell. They undertake a variety of tasks that are essential for life. Most proteins function in assemblies rather than individually. Protein function is strongly correlated to structure...
In this dissertation, the work presented describes an integrated microfluidic system composed of pressure driven perfusion and online measurement techniques for analyses of hepatic metabolism. The liver is primarily made up of...
A new polyene cyclization strategy exploiting β-ionyl derivatives was developed. Photoinduced deconjugation of the extended π-system within these chromophores unveils a contrathermodynamic polyene that engages in a Heck bicyclization to...
Hop (Humulus lupulus L.) is an important crop worldwide, known as the main flavoring ingredient in beer. The diversifying brewing industry demands variation in flavors, superior process properties, and sustainable agronomics, which are...
Small helical membrane proteins are functionally very important. They are involved in many cellular transport and signal transduction pathways maintaining the chemical, mechanical and electrical potentials of cells. They constitute...
The innate immune system acts as the first line of defense against invading pathogens throughrecognition of pathogen associated molecular patterns or danger associated molecular patterns. Several germline encoded receptors, known as the...
Presently, green chemistry is a movement that proactively seeks to create alternative and earth-friendly processes. It is a growing field open for innovation and cost-effective measures to enrich the scientific community while catering...
Biogenesis of eukaryotic ribosomes is a complicated process that needs to be highly coordinated and tightly regulated. The small nucleolar ribonucleoprotein particles (snoRNPs) mediate the first step of ribosome biogenesis by carrying...
Collective protein structural transitions couple with fluctuations of their aqueous environment to enable biological function. Although decades of experiment have investigated protein-motion hy- dration couplings, atomistic details...
The discovery of Cas9, a large protein that involves in all processes the type II system of Clustered Regularly Interspaced Short Palindromic Repeat, an adaptive immune system from bacteria and archaea, is a paradigm shifting molecular...
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) interference is a newly discovered small-RNA based immune system used by bacteria and archaea. One of the essential steps in this interference is to process long CRISPR...
Towards Structural Elucidation of Proteins, Glycoproteins, and Protein-Ligand Complexes Using Tandem Trapped Ion Mobility Spectrometry-Mass Spectrometry (Tandem-TIMS/MS)
Ion mobility spectrometry-mass spectrometry (IMS-MS) is playing an emerging role in structure elucidation of biomolecules. IMS-MS has certain advantages over traditional biophysical tools due to its high sensitivity and fast measurement...
Despite the importance of membrane proteins for cellular functions, membrane proteins remain one of the most challenging arena of structural biology. A significant progress has been made in the recent years to overcome challenges...
This dissertation focuses on the development of novel chemical reactions for enhancing the efficiency of synthesis. In particular, we disclose the development of a tandem fragmentation-olefination reaction for the synthesis of 1, 6-enynes...
Non-covalent molecular interactions are a ubiquitous part of molecular interaction and the driving force behind macromolecules and host-guest binding. However, a more recent non-covalent molecular interaction, the cation-π interaction, ...
Since antiquity, alkaloid natural products have served as medicinal ingredients that still contribute as an inspiration for the development of novel therapeutics. For the synthetic chemist, much of the importance of natural products lies...
Fusicoccin A is a diterpene glycoside phytotoxin which stabilizes 14-3-3 protein-protein interactions. The unique structure contains a 5-8-5 carbotricyclic framework which, when decorated with distinct substitution patterns, is found in...
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) interference is a newly discovered small-RNA based immune system used by bacteria and archaea. One of the essential steps in this interference is to process long CRISPR...
The trafficking of proteins between intracellular compartments must be tightly regulated in order to maintain cellular balance. Early secretion form the endoplasmic reticulum is mediated by a complex of five coat proteins forming the...
Generally, the long-range electronic communication between orthogonal orbitals is inefficient and limited to field and inductive effects. We illustrate how substituent effects can be transferred between orthogonal orbitals when the...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
