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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
OVX leads to hyperphagia and weight gain in female rats, which can be prevented by E2; however, the role of endogenous E2 on feeding and energy homeostasis in female mice has not been well characterized. The 2-part goal of this study was...
Previous studies have shown the bluefin killifish, Lucania goodei, to be a useful model for investigating the role of environment in driving visual system evolution and plasticity (Fuller et al 2003, 2004, 2005). Environmental plasticity...
Self-sustaining oscillators regulate diverse aspects of physiology in mammals such as insulin secretion, cell cycle regulation, and circadian rhythmicity. The circadian clock is based upon several interacting feedback loops, which affect...
Extracellular vesicles (EVs) include exosomes and microvesicles, and are important mediators of cell-to-cell communication in healthy and pathological environments. Packed with biological information and present in a variety of...
Circadian rhythms in mammals are generated by a negative transcriptional feedback loop in which PERIOD (PER) is rate-limiting for feedback inhibition. Casein kinases Iδ and Iε (CKIδ/ε) can regulate temporal abundance/activity of PER by...
In addition to the known behavioral and cognitive impairments, including memory deficits, depression, and anxiety associated with traumatic brain injury (TBI), there is an increased risk for new onset heavy weekly drinking, binge...
The process of normal wound repair after tissue injury follows a closely regulated sequence involving inflammation, the recruitment, activation and proliferation of fibroblasts and the secretion of extracellular matrix, which culminates...
Characterization of Mechanisms Controlling Translational Regulation of Type I Collagen in Liver Fibrosis as Target for Novel Anti-Fibrotics and the Regulation of Neural Tube Closure during Embryonic Development
Pathological hepatic fibrosis represents a worldwide medical problem with substantial mortality and the number of cases is increasing. Despite all medical advances, effective therapy to treat progressive liver fibrosis is still...
Stress is a ubiquitous aspect of everyday life. As such, there exists a great deal of variability in the individual response to stress, particularly as a functional cause of depression. The aim of this dissertation is to investigate the...
The 5' stem-loop (5'SL) in the 5' UTR of collagen α1(I) and α2(I) mRNAs is the key element regulating stability and translation of collagen mRNAs. LARP6 is the RNA binding protein which exhibits high affinity binding to the 5'SL of...
Circadian rhythms are 24-hour daily rhythms in transcription, translation, hormone release, electrical activity, and other behaviors. Rhythms are primarily generated in different brain areas and tissues by input from the suprachiasmatic...
Yin Yang 1 (YY1) is a highly conserved, multifunctional zinc finger transcription factor. It has been shown to regulate genes involved in cell cycle regulation, apoptosis, cell growth and proliferation, differentiation, and development....
Alzheimer’s disease is a progressive neurodegenerative disorder and the most common form of dementia. Like many neurological disorders, Alzheimer’s disease has a sex-biased epidemiological profile, affecting approximately twice as many...
As the global burden of depression continues to rise, development of more efficacious and faster-acting antidepressant treatments has remained stagnant over several decades. This has created a dire need for a newer generation of...
Anxiety and depressive disorders are the most common of all psychiatric disorders; however, current human and animal research has yet to provide a clear understanding of the neural mechanisms underlying their etiology. Demographic...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
