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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The maize (Zea mays L) initiator-binding protein2 (IBP2) gene is known to encode a protein, IBP2, with promoter-binding activity. IBP2 also resembles telomere DNA-binding proteins from other plant species. Therefore, we investigated...
Interferon (IFN)-mediated innate immune response is the first line of defense against viral infections. And interferon regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN stimulated genes (ISGs) and is...
The Zika virus (ZIKV) presents a threat to the health of pregnant women and developing fetuses as it is associated with microcephaly. There is a current gap in the understanding of how ZIKV affects the host’s chromatin architecture....
Hydrogen/Deuterium Exchange Monitored by Liquid Chromatorgaphy Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry—Method Optimization and Applications to the Study of Protein Conformation and Protein—Drug Interactions
Proteins are the most versatile macromolecules in the cell. Major biochemical functions of proteins include binding; catalysis; and serving as structural components of cells and organisms. Proteins are made of amino acids that are...
A hallmark of cancerous transformation is altered chromosome structure. Inappropriate regulation of chromatin structure inhibits normal cell function, and may represent the origin of transformation. A handful of important studies have...
ORF45 of Kaposi's sarcoma–associated herpesvirus (KSHV) is a gamma herpesvirus-specific, immediate-early, and tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this...
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus that has adapted unique mechanisms to modulate the cellular microenvironment of its human host. The pathogenesis of KSHV is intimately linked to its manipulation of...
The relationship between protein structure and the specificity of substrate oxidation remains a key problem in the study of the lipoxygenase enzyme family. Polyunsaturated lipid substrates reach the non-heme iron contained within the...
The evolutionary arms race for survival against phages and other mobile genetic elements has produced a wide repertoire of defensive strategies in prokaryotes. CRISPR (Clustered, regularly-interspaced, short palindromic repeats) systems...
With more influenza A virus sequence data available than before, researchers have paid more attention to how to utilize these data to predict the influenza A virus evolution trend. There are diverse opinions on that. Some researchers...
XCI is a form of dosage compensation that is established in early development of female mammals where one X chromosome is randomly silenced, thus balancing expression of X-linked genes. XCI is achieved by many cis- and trans- elements...
Regular emergence and re-emergence of viral pathogens emphasizes the importance of understanding viral biogeography and migration. Single-stranded DNA (ssDNA) viruses are among the least understood groups of microbial pathogens, yet the...
Pathogenic microorganisms gain entry inside the host cell by breaching anatomical barriers andinvading tissues. The host cell in turn depends on the sentinels of cell autonomous defense system to fight off the invading pathogen. This...
Escherichia coli NADPH-dependent assimilatory sulfite reductase, SiR, provides reduced sulfur for assimilation into biomass. The ability of SiR to perform its high-volume electron transfer reaction without the release of partially...
Gene expression and regulation in early vertebrate development has been examined in Xenopus laevis, a model organism for embryonic developmental biology. Two related projects were carried out and they are described in separate chapters....
Characterizing the Relationship Between Williams Syndrome Transcription Factor and Heterochromatin Maintenance Through the Targeted Disruption of the BAZ1B Gene
Maintaining genome integrity and epigenetic programming is essential to avoid disease and retain the identity and proper function of the multitude of specialized differentiated cell types in the body. Much progress has been made in the...
The development of multicellular animals involves a diverse array of cellular processes, including cell differentiation, proliferation, and polarization. The control of these processes is largely governed by communication between...
Yin Yang 1 (YY1) is a highly conserved, multifunctional zinc finger transcription factor. It has been shown to regulate genes involved in cell cycle regulation, apoptosis, cell growth and proliferation, differentiation, and development....
Hydrogen/Deuterium Exchange Monitored by Liquid Chromatorgaphy Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry—Method Optimization and Applications to the Study of Protein Conformation and Protein—Drug Interactions
Proteins are the most versatile macromolecules in the cell. Major biochemical functions of proteins include binding; catalysis; and serving as structural components of cells and organisms. Proteins are made of amino acids that are...
Characterization of the Subcellular Localization of ORF52/KicGAS and Functional Roles during the Life Cycles of Kaposi's Sarcoma-Associated Herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that causes Kaposi's sarcoma (KS) and two lymphoproliferative diseases. We previously reported KSHV ORF52/KicGAS (KSHV inhibitor of cGAS) to inhibit cGAS (cyclic GMP...
The vertebrate neural retina acts as a light detector, where photons are transduced into chemical and electrical signals at the brain. Phototransduction takes place in the photoreceptor cell outer segment (OS). Rods are responsible for...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
