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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has been linked to severe neurological disorders such as microcephaly in newborns as well as Guillain-Barré syndrome in adults. It is closely related to other flaviviruses...
During the past 30 years, there have been several Flaviviridae threats. Among them, Hepatatis C virus (HCV) emerged in the Western hemisphere as the previously unidentified etiological agent of non-A non-B hepatitis in transfusion...
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus of significant public health concern closely related to other highly pathogenic flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV). With the rise of ZIKV in...
Hepatitis C virus (HCV) infection leads to acute and chronic liver disease for thousands of people every year. With the absence of an effective treatment method, new classes of anti-HCV therapies are needed. Cyclosporine (CsA) and its...
Flaviviruses are positive sense single-stranded enveloped RNA viruses, most are mosquito-transmitted viruses that cause systemic infection as they disseminate through the bloodstream in vertebrate hosts. The members of the flavivirus...
Zika virus is an arbovirus that has reemerged in recent years as a global health concern. A member of the Flavivirus genus, Zika virus is closely related to other major human pathogens such as dengue virus and West Nile virus, but each...
Cyclophilin A (CyPA) and its peptidyl-prolyl cis/trans isomerase (PPIase) activity plays an essential role in hepatitis C virus (HCV) replication. Mounting evidence indicate nonstructural protein 5A (NS5A) of HCV as the major target of...
Hepatitis C virus (HCV) has emerged as a major cause of human liver disease, with ~3% of the world population persistently infected with and more than one million new cases of infection reported annually. In most cases, HCV escapes the...
Hepatitis C virus (HCV) is an enveloped RNA virus that often manifests into chronic infections of the liver, which represents a threat to human health due to the morbidity it presents within infected patients. The virus is especially...
The hepatitis C virus (HCV) is a serious health threat globally. Current therapies are not tolerated well, have a low response rate, and there is no available vaccine. New viral targets for drugs are urgently needed. The aim of this...
Short Hairpin RNAs Delivered by Lentiviral Vector Transduction Trigger RIG-I-Mediated IFN Activation and Isolation of HCV with Enhanced Kinetics and Viral Assembly
Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, ...
Zika virus (ZIKV) is a mosquito-borne flavivirus in the family Flaviviridae. Since being isolated from a rhesus macaque monkey in the Zika Forest of Uganda in 1947, only sporadic cases had been reported in Africa and Asia until 2007 when...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
