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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
As an RNA-guided RNA modification enzyme, the box H/ACA RNP recruits the guide RNA to recognize the substrate RNA, whereas the protein partners carry out the catalysis. Most intriguingly, box H/ACA RNPs share the same four conserved...
The striated muscle Z-line is a complex network of proteins in which N-terminal domains of titin interact with the actin filament cross-linker alpha-actinin, and other proteins to establish and maintain the structural integrity of the...
Unraveling the detailed molecular mechanisms involved in muscle contraction is a prerequisite for understanding the molecular basis of muscular disorders. Since myosin is the motor of the muscle contractile system and troponin plays a...
The focus of this study is a prototypical member of the lipoxygenase protein family (acc. PF00305), soybean lipoxygenase-1 (LOX-1). I am interested in two aspects of this enzyme: a comparison of its structure and sequence with...
Adeno-associated virus type-2 (AAV-2) is a leading candidate vector for gene therapy. My PhD is a part of the ongoing research project towards the long-term goals of engineering AAV to evade immune neutralization when repeated doses are...
Cargo trafficking using vesicles has been studied in eukaryotic cells for more than half a century. Three conventional and evolutionarily archaic pathways have since been identified. These pathways include: Coat Protein II (COPII), Coat...
The discovery of Cas9, a large protein that involves in all processes the type II system of Clustered Regularly Interspaced Short Palindromic Repeat, an adaptive immune system from bacteria and archaea, is a paradigm shifting molecular...
Recent years have seen a dramatic worldwide increase in allergies and asthma that can now be described as reaching epidemic proportions. Food allergies affect approximately 2% of the adult population and up to 6% of the pediatric...
The mechanism by which muscle generates force has been the subject of considerable study. Key to our understanding of this mechanism is the conformational changes occurring in the myosin "head" as it interacts with the thin filament....
Ribosomes are giant RNA-protein complexes responsible for translating the information encoded by the genome to create the proteome in all kingdoms of life. In budding yeast, the mature cytoplasmic 80S ribosome consists of 79 ribosomal...
The vertebrate neural retina acts as a light detector, where photons are transduced into chemical and electrical signals at the brain. Phototransduction takes place in the photoreceptor cell outer segment (OS). Rods are responsible for...
Structural biology is a fundamental tool for addressing critical biological and medical questions. Cryogenic electron microscopy (Cryo-EM) is a powerful technique within this field, and although still in its early stages, it has become...
Cryogenic electron microscopy (Cryo-EM) techniques have been rapidly developing over the past decade, enabling faster, better structure determinations of many samples. However, there are still some samples presenting challenges for cryo...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
