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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Integrin signaling is critical for many biological functions including cell survival, cell migration, development, immunity and wound healing. Integrins perform their function through a structural change that is propagated from the...
Muscle generates force through the interaction between myosin cross-bridges and actin filaments. This study is part of a research project that aims to understand the molecular mechanism of force production through direct visualization of...
We describe a cryo-electron microscopy 3D image reconstruction of relaxed myosin II-containing thick filaments from the flight muscle of the giant waterbug Lethocerus indicus. The relaxed thick filament structure is a key element of...
Insect flight muscle (IFM) is the preferred model system for visualizing actin-myosin interactions due to its highly ordered lattice of actin and myosin filaments. Electron tomography (ET) of fast-frozen, actively contracting Lethocerus...
Cell adhesion assemblies occur at sites where cells either contact each other or components related to the extracellular matrix. They provide the structural integrity needed to support nonmigrating cells via a host of transmembraneous...
Myosin V, as a member of the myosin family, can "walk" along F-actin to transport many "cargos", such as mRNA and secretary vesicles, to its destination. This study is part of a research project that aims to understand the interaction...
We use a lipid monolayer system to prepare paracrystalline rafts of F-actin with two different cross-linking proteins, α-actinin and villin. α-Actinin cross-links F-actin into relatively loose networks throughout cells, while villin...
Muscle plays a primary role in movement of the body of multicellular organs. A study of muscle contraction at a molecular level will provide understanding of muscular malfunction, as well as insights into the basic mechanism of...
The introduction of cryo-electron microscopy (cryo-EM) has greatly improved our understanding of structural biology, especially regarding muscle tissue. This technique has been key in revealing the complex structure and functional...
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