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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The 26S proteasome is the largest and most complicated chambered protease known. It is responsible for regulated degradation of proteins within all eukaryotic cells, and is essential for maintaining protein homeostasis. Disruptions to...
Accurate chromosome segregation is vital to maintain genomic integrity. Chromosome missegregation, or aneuploidy, contributes to cancer development and conditions like down syndrome (Trisomy 21). Chromosomes are attached to microtubules...
The faithful maintenance of structure and function of chromatin is crucial for maintaining genomic stability. In proliferating cells, nucleosome assembly occurs largely during S-phase with a strict coordination between DNA and histone...
This dissertation focuses on microtubule assembly mechanisms and functions in dividing and non-dividing cells. In dividing cells, centrosome is the major microtubule-organizing center (MTOC). Ninein (Nin) is a centrosomal protein whose...
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects. Bipolar kinetochore attachment is required for SAC silencing which allows for anaphase onset and the release of the phosphatase, ...
The centrosome, comprised of a pair of centrioles, is the best-studied microtubule-organizing center (MTOC). However, after utilizing the centrosome to organize the mitotic spindle during cell division, differentiated cells will often...
The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding. Misfolded proteins are aggregation prone and protein aggregation are associated with many human diseases, ...
Tight regulation of the cell cycle is essential to maintain genome integrity. Errors at any stage during cell cycle, including replication, chromosome segregation, and mitotic exit, can lead to genome instability, which has been shown to...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
