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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The photophysical characteristics of 5-arylvinyl-5Oe-methyl-2, 2Oe-bipyridyls (AVMB) and their zinc complexes were investigated in order to recognize the factors that influence the emission band shift and fluorescence quantum yield change...
This dissertation presents studies by magnetization, dc magnetic susceptibility and EPR spectroscopy on several new spin-frustrated polyoxometalate (POM) lattices of increasing spin sizes and complexities. Measurements have been made...
This dissertation has focused on studying the electron spin dynamics in the quantum and classical limit and, most importantly, at the quantum-classical boundary. We have successfully used high frequency electron paramagnetic resonance ...
This dissertation attempts to provide insight into the mixing, hydration and annealing of self-assembled, multilayered films based on precise counting of their doping ions and water content. Several practical applications are then...
Integrin signaling is critical for many biological functions including cell survival, cell migration, development, immunity and wound healing. Integrins perform their function through a structural change that is propagated from the...
Tissue engineering is one of the fastest growing biotechnology industries. The overarching research goals of the tissue engineering industry are highly intertwined with the field of medicine. The tissue engineering field seeks to create...
This work describes the activation profiles and regulatory cascades of the human kallikrein-related peptidases. The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases, comprising 15 members (KLK1–15)...
Damage continues to plague the structural integrity of polymer composites. Continued stress leads to cracking and weakening of a composite system. Engineering polymer composites with carbon nanotube reinforcements and self-healing...
Solution-Phase Hydrogen/Deuterium Exchnage Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Technique Development and Application to Muscle Biochemistry
Proteins are vital macromolecules of every living cell. They undertake a variety of tasks that are essential for life. Most proteins function in assemblies rather than individually. Protein function is strongly correlated to structure...
Diphtheria toxin repressor is a regulatory protein from Corynebacterium diphtheriae, the causal agent of Diphtheria. The diphtheria toxin repressor (DtxR) contains an SH3-like domain that forms an intramolecular complex with a proline...
In the presence of water vapor, photolysis of tropospheric ozone (O3) produces the hydroxyl radical (OH), which is a strong oxidant that directly and indirectly controls a host of greenhouse gases and air pollutants. When tropospheric O3...
Small nucleolar RNAs (snoRNAs) are localized in the nucleolus as small ribonucleoprotein particle (snoRNP) that are RNA-protein complexes and catalyze site specific modifications on the ribosomal RNA. When compared to many protein...
This dissertation studies the size- and site-dependent optical and magnetic properties of II-VI quantum dots (QDs). The first chapter provides a theoretical background used to analyze the data and the properties expected for diluted...
Extended Metal Atom Chains (EMACs) are compounds that consist of three or more metal atoms that are directly bonded with the support of equatorial organic ligands. This dissertation is focused on the high frequency electron magnetic...
CRISPR-cas systems have been found to confer RNA guided immunity in prokaryotes comparable to the eukaryotic RNA interference. These Clustered Regularly Interspaced Short Palindromic Repeats, as their name entails, are repeated sequences...
One of the mechanisms of cardiac arrhythmias is the self-organization of electrical waves in the heart. These waves can anchor to scar tissue, collagen fibers, and coronary vessels. The anchoring generates stationary electrical signals...
Viral capsids must assemble into stable structures that resist dissociation in extreme environments between hosts yet they simultaneously must be unstable enough to release their genome upon infection. The conflicting functions that the...
All functional RNAs contain post-transcriptionally modified nucleotides. 2'-O-ribose methylation and pseudouridylation are the two major types of modifications, which occur by box C/D and box H/ACA ribonucleoprotein (RNP) complexes, ...
Human glucokinase is a 52 kDa single polypeptide chain containing 465 amino acids and a single binding site. It catalyzes the ATP dependent phosphorylation of glucose in the beta pancreatic cells, which ultimately serves as the glucose...
Materials synthesis far from thermodynamic equilibrium can yield hierarchical order that spans from molecular to macroscopic length scales. Here we study the formation of microscopic and macroscopic inorganic tubes during spatially...
Two-dimensional gel electrophoresis (2-DE) is used to compare the protein profiles of different crude biological samples. Narrow pH range Immobilized pH Gradient (IPG) strips were designed to increase the resolution of these separations....
Breast cancer is the second leading death-causing cancer in women, after lung cancer. Breast cells are normally responsive to the estrogen hormone as they have the receptor for it. Breast cancer types that express the estrogen receptor...
Reproduced with permission from Journal of the American Chemical Society, submitted for publication. Unpublished work copyright 2008 American Chemical Society. The development of ternary nanoscale materials with controlled cross...
Orientational restraints resulting from a wide range of anisotropic nuclear spin interactions such as chemical shifts, heteronuclear dipolar interactions, and quadrupolar interactions, have been widely used for determining the structures...
Considerable attention has recently been given to the preparation of the ciguatoxins, the major group of toxins implicated with the onset of ciguatera fish poisoning (CFP) – a seafood-borne illness associated with the consumption of reef...
This thesis analyzes the structure and function of enzymes involved in the biosynthesis of the tetrapyrrole cofactor, siroheme, a critical cofactor used in sulfur and nitrogen metabolism in plants, bacteria, and some archaea. The...
The properties of proteins with reduced sequence complexity--either in the form of primary structure symmetry or restricted amino acid alphabets--are controversial. Studies of protein biophysics and sequence analyses suggest that...
IdeR is an iron-dependent repressor protein, one of the essential proteins found in Mycobacterium tuberculosis. IdeR is a homologue of the diphtheria toxin repressor (DtxR). IdeR controls iron acquisition and storage, moreover it binds...
Box H/ACA ribonucleoprotein particle (RNP), an RNA-guided RNA modification enzyme, is comprised of four conserved proteins (Cbf5, Nop10, Gar1 and L7Ae) and one guide RNA. This complex recognizes the substrates by the guide RNA and...
M2 is an important drug target, this transmembrane protein forms a tetrameric proton channel essential for the life cycle of the Influenza A virus. The recent S31N mutation rendered this protein resistant to the used antiviral drugs, ...
Metal flux synthesis was used to discover new Zintl phase materials and to grow crystals of superconducting phases. Reactions of barium and the pnictide elements Pn = P or As in indium melts produced new Zintl phases Ba2In5Pn5. This...
Nanoparticle based cellular therapies hold great promise for clinical applications and medicinal use in human patients by allowing for targeted delivery of a personalized medicine payload to specific cells and tissues in a variety of...
Recent studies have shown the importance of enzyme regulation through the formation of higher order structures. This is exemplified by Acetyl coenzyme A Carboxylase, and Cytidine Triphosphate synthase, two enzymes that form long chain...
Microwave reactors offer convenience in sealed tube, high temperature reactions that can lower reaction time, increasing the value of certain synthetic procedures. Benzylation of alcohols, carboxylic acids and arenes using 2-benzyloxy-1...
The gasification of carbonaceous material is a long standing industrial process which produces valuable feed stocks of H2 and CO gas (Syngas) that can be reacted further resulting in extended hydrocarbons for use in numerous areas of...
In Chapter I, the photochemistry of enediynes is reviewed. Photo-Bergman cyclization, C1-C5 photocyclization and other photochemical reactions of alkynes in the enediyne moiety are discussed. DNA cleavage by photochemically activated...
BAD is a pro-apoptotic member of the Bcl-2 family of cell death regulators. The Bcl-2 family controls the permeability of the outer mitochondrial membrane via interactions between pro- and anti-apoptotic members of the family. Once the...
This dissertation presents and evaluates the unique interplay between nanoparticle structure, environment, and electronic energy relaxation. This knowledge will provide useful information for tailoring nanoparticle properties so that...
Xeroderma Pigmentosum (XP) is an autosomal recessive disorder characterized by extreme sensitivity to sunlight, higher incidence of skin cancers, pigmented alterations in the skin, and in some cases neurological abnormalities. XP is...
RNA-RNA interactions involved in recognition associated with ribozyme catalysis are essential for ribozyme function. Research described in this dissertation focuses on RNA-RNA interactions at, and in the vicinity of two splice sites of...
In eukaryotes and archaea 5-25% of transfer RNA (tRNA) precursors contain intervening sequences, or introns, that interrupt the molecules' functional regions. Because functional tRNA molecules are necessary for protein synthesis, ...
As the world's reserves of light crude oil are depleted, the fuel industry will have to find other sources to generate transportation fuels. There are known supplies of unconventional crude oil (bitumen) in Canada, but it is more...
Asphaltenes are a solubility defined class of crude oil compounds that precipitate from solution upon normal alkane addition. They are experimentally investigated due to their tendencies to cause refinery issues. Their ability to...
A generalized ensemble based enhanced sampling scheme, the Orthogonal Space Sampling (OSS) approach, is introduced in this thesis. Due to the fact that the OSS scheme simultaneously accelerates the motions of a target event and its...
The current treatment for hepatitis C virus (HCV) consists of a combination therapy of alpha interferon (IFN-alpha) and ribivirin (RBV). Due to IFN resistance and side effects, new classes of drugs are needed to combat HCV infection....
This thesis details our studies of the ultrasonic degradation of copolymers, to provide future investigators with information discerning the effect of monomeric arrangement on the transient elongational flow-induced degradation of...
Cancer cells have been considered the major player in tumor development. However, recent studies indicate that epithelial-stromal interactions play a crucial role in cancer initiation, progression, and metastasis. The prevalence of...
Metal eutectic fluxes are useful for exploratory synthesis of new intermetallic phases. In this work the use of cerium/transition metal eutectics such as: Ce/Co, Ce/Ni, and Ce/Fe have yielded many new synthetically and magnetically...
Ultrathin films consisting of an alternating sequence of positively and negatively charged polyelectrolytes have been prepared by means of the electrostatic layer-by-layer sequential assembly technique. To augment their typical...
Notch signaling plays an important role in tissue differentiation and remodeling and has been extensively studied. Much has been learned about the Notch signaling pathway and consequences of defects within the path, yet little is...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
