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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The precise regulation of cellular and hormonal signaling pathways is required for proper development in metazoan organisms. The Drosophila imaginal wing disc is the ideal model system for the study of cellular signaling regulating...
The follicular epithelium (FE) of the Drosophila egg chamber is an excellent model system to study cell-cycle regulation, cell differentiation and cell migration in development. During oogenesis, follicle cells sequentially undergo three...
This study examined the transgenerational relationship between the prevalence of maternal childhood traumas for justice-involved adolescent mothers and her baby's social and emotional risk by the age of 24 months. Two separate variables...
Many diseases such as DiGeorge syndrome, leukemia and likely all cancers display abnormal replication timing, the temporal order in which segments of chromosomes are replicated. However, the elements that regulate normal replication...
Drosophila melanogaster serve as an excellent model to study the highly conserved notch signaling pathway, which is involved in a broad array of developmental events. The Notch signal transduction pathway in Drosophila is vastly complex...
Mitochondria, important energy centers in the cell, also control sperm cell morphogenesis.Drosophila spermatids have a remarkably large mitochondrial formation called the nebenkern. Immediately following meiosis during sperm development, ...
In previous work, Striegel and Hurdal have developed a mathematical model for cortical folding pattern formation during development (Striegel). A Turing reaction-diffusion system and a prolate spheroid domain were used to model the shape...
Cellular signaling pathways constitute series of genes widely used in a multitude of molecular processes within an organism. Generally, the activation of these pathways is relatively upstream in the sequence of developmental events...
Type 2 diabetes, the more prevalent form of diabetes mellitus, is caused by insulin resistance in peripheral tissues due to a post-receptor defect in the insulin-signaling pathway. Binding of insulin to its receptor in the cell membrane...
The small golden ant Pheidole morrisi Forel is the most common ant of the Apalachicola National Forest, a typical longleaf pine flat-woods ecosystem and is found in pine forests across the eastern U.S. P. morrisi likely plays a...
The neurophysiological foundation and anatomical basis of circuits necessary for adult behaviors are established early in development. Numerous perinatal and postnatal variables affect circuit trajectory during developmental sensitive...
Improving the Accuracy of 3D Chromosome Structure Inference and Analyzing the Organization of Genome in Early Embryogenesis Using Single Cell Hi-C Data
This dissertation summarizes my graduate work on the structure and organization of mouse genome during preimplantation development. My research is divided into three different areas, which I will discuss in turn. To begin, I will discuss...
Autosomal recessive primary microcephaly (MCPH, MIM 251200) is a neurodevelopmental disorder that results from a loss of neural progenitors in the embryonic neocortex. Patients with MCPH have a significantly small brain and exhibit...
In Drosophila melanogaster, cells that are normally viable in homogeneous tissue can be eliminated when surrounded by cells with a different level of expression of a certain gene, such a phenomenon has been termed cell competition. A...
Transition zones are regions in the animal body where two types of epithelial tissue meet. Many transition zones are known high-risk sites for tumorigenesis. However, little is known on why transition zones are more susceptible to tumor...
The interaction between various signaling pathways and their spatial and temporal regulation during growth and development remains largely unknown. The purpose of this thesis is to investigate the role of signaling pathways involved in...
Characterizing Non-Typical Epithelial Behavior: Analysis of the Spatiotemporal Patterns of Patency, and a Study of Nonautonomous Cellular Compaction in Drosophila Melanogaster Follicular Epithelium
The follicular epithelium (FE) in the Drosophila melanogaster ovary is an excellent model system to study epithelial processes and behaviors, such as cell-cell communication, cell cycle regulation, and epithelial morphogenesis. The...
The mobile and self-perpetuating nature of transposons allows them to impact organisms in a polarized manner: as an evolutionary force in increasing genome size and as molecular parasites whose activities may lead to potentially...
During the age of non-avian dinosaurs, ancestors of present-day mammals were likely small insectivores, relegated to nocturnal and subterranean niches. This nocturnal "bottle-neck" is postulated as a driving force of numerous...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
