What is the Best Treatment for an Adult Whose Asthma Exacerbation Has Not Completely Responded to 5 Days of Oral Corticosteroids?

Current guidelines recommend that patients with acute asthma exacerbations be treated with systemic corticosteroids for 5 to 10 days, so continued steroid therapy is an option. However, limited evidence suggests that a 2-week course of oral steroids may be no more effective than a 1-week course (SOR C, based on a single small randomized controlled trial with a trend favoring prolonged therapy).