Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Yip, R., Li, K., Liu, L., Xu, D., Tam, K., Yankelevitz, D. F., … Henschke, C. I. (2018). Controversies on lung cancers manifesting as part-solid nodules. European Radiology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28835992
Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs <80% or category PSNs ≥80%. Twenty studies reported on PSNs <80%: 7 reported DFS and 2 OS of 100%, 6 DFS 96.3-98.7%, and 11 OS 94.7-98.9% (median DFS 100% and OS 97.5%). Twenty-seven studies reported on PSNs ≥80%: 1 DFS and 2 OS of 100%, 19 DFS 48.0%-98.0% (median 82.6%), and 16 reported OS 43.0%-98.0% (median DFS 82.6%, OS 85.5%). Both DFS and OS were always higher for PSNs <80%. A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component. • Lung cancers manifesting as PSNs are slow growing with high cure rates. • Upper limits of the solid component are important for correct interpretation. • Consensus definition is important for the management of PSNs. • Median disease-free-survival (DFS) increased with decreasing size of the nodule.
Yip, R., Li, K., Liu, L., Xu, D., Tam, K., Yankelevitz, D. F., … Henschke, C. I. (2018). Controversies on lung cancers manifesting as part-solid nodules. European Radiology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28835992