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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The 14-3-3 family of proteins is implicated in the regulation of a broad range of key neuronal processes. Previous human and animal studies have provided evidence for an association between 14-3-3 proteins and schizophrenia. Here, I...
The secondary injury cascades in the acute phase of traumatic brain injury (TBI) are often the most devastating to patient outcome. These cascades include the neurobiological and neurochemical changes subsequent to the mechanical trauma...
Alzheimer's disease (AD) currently underlies dementia for tens of millions of people worldwide, and its occurrence is set to double in the next 20 years. The currently approved drugs for treating AD only marginally ameliorate cognitive...
Maintenance of the integrity of the genome is vital to survival and the small non-histone protein Heterochromatin protein 1 (HP1) plays an important role in the process. Here we demonstrate two roles for HP1 in regulating transcription...
The faithful maintenance of structure and function of chromatin is crucial for maintaining genomic stability. In proliferating cells, nucleosome assembly occurs largely during S-phase with a strict coordination between DNA and histone...
LARP6 in Type I Collagen Expression and Embryonic Development: Role in Partition of Collagen mRNA to ER Membrane and in PIh1D3 Mediated Xenopus Development
Excessive production of Type I collagen is the hallmark of fibrotic disorders. The production of Type I collagen is mainly regulated at post-transcriptional level by a COLLAGEN mRNAs binding protein La ribonucleoprotein domain family...
The zebra finch (Taeniopygia guttata) has long been used as an animal model for memory and cognition due to the naturally occurring process through which they acquire and produce song This process, in which song is learned from tutor...
A Tale of Two Drosophila Centrosome Proteins: The Regulation of Cilium Functions by Rootletin, and the Conversion of Sperm Mitochondria into Microtubule-Organizing Centers by CnnT
Using the fruit fly Drosophila melanogaster as a model organism, this dissertation dissects molecular and biological functions of three proteins: Rootletin (Root), testis-specific Centrosomin (CnnT) and Spermitin (Sprn). Centrosomes are...
Characterization of Mechanisms Controlling Translational Regulation of Type I Collagen in Liver Fibrosis as Target for Novel Anti-Fibrotics and the Regulation of Neural Tube Closure during Embryonic Development
Pathological hepatic fibrosis represents a worldwide medical problem with substantial mortality and the number of cases is increasing. Despite all medical advances, effective therapy to treat progressive liver fibrosis is still...
The 5' stem-loop (5'SL) in the 5' UTR of collagen α1(I) and α2(I) mRNAs is the key element regulating stability and translation of collagen mRNAs. LARP6 is the RNA binding protein which exhibits high affinity binding to the 5'SL of...
Autosomal recessive primary microcephaly (MCPH, MIM 251200) is a neurodevelopmental disorder that results from a loss of neural progenitors in the embryonic neocortex. Patients with MCPH have a significantly small brain and exhibit...
Genome analysis in several eukaryotes shows a surprising number of transcripts that do not encode conventional messenger RNAs. Once considered noise, these non-coding RNAs (ncRNAs) appear capable of controlling gene expression by various...
Protein aggregates formation is a common characteristic of many neurodegenerative diseases including Parkinson's disease (PD), Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). Effective clearance of those toxic protein...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
