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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Polyelectrolytes can be used in a variety of forms from Layer-by-Layer assembled thin films to spun polyelectrolyte complex as free-standing membranes. The Layer-by-Layer methodology is used to adsorb oppositely charged polyelectrolytes...
This dissertation describes the development of alternative products from the copper-catalyzed azide-alkyne cycloaddition (CuAAC). The first chapter provides an introduction to the CuAAC through the historic timeline of the development of...
The work in this dissertation presents methods developed for the measurement of small molecules in islets of Langerhans, including reactive oxygen species and amino acids. Reactive oxygen species were measured using fluorescence imaging....
Human mesenchymal stem cells (hMSCs) isolated from bone marrow have multi-lineage differentiation potential and have attracted considerable attention in bone tissue regeneration. However, previous studies have shown that 2D-expanded...
When cells encounter DNA replication stress, the S-phase checkpoint is activated to facilitate cell cycle arrest and DNA repair. An important aspect of the checkpoint is the transcriptional response, but the details governing this...
Excluding skin cancers, prostate cancer is the most frequently diagnosed cancer in American men. The American Cancer Society estimated 220, 800 new prostate cancer cases would be diagnosed in 2015. Prostate cancer is also the second...
Human mesenchymal stem cells (hMSCs) are considered as a novel candidate for cell therapy due to the differentiation potential, migration ability, and secretion function. Late stage clinical trials require a large amount of cells that...
A Tale of Two Drosophila Centrosome Proteins: The Regulation of Cilium Functions by Rootletin, and the Conversion of Sperm Mitochondria into Microtubule-Organizing Centers by CnnT
Using the fruit fly Drosophila melanogaster as a model organism, this dissertation dissects molecular and biological functions of three proteins: Rootletin (Root), testis-specific Centrosomin (CnnT) and Spermitin (Sprn). Centrosomes are...
Autosomal recessive primary microcephaly (MCPH, MIM 251200) is a neurodevelopmental disorder that results from a loss of neural progenitors in the embryonic neocortex. Patients with MCPH have a significantly small brain and exhibit...
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