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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has been linked to severe neurological disorders such as microcephaly in newborns as well as Guillain-Barré syndrome in adults. It is closely related to other flaviviruses...
Eukaryotic genomes replicate via the synchronous firing of clusters of origins that together produce multi-replicon domains, each of which replicates at a defined time during S-phase. This temporal program is termed the DNA replication...
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local...
Epithelial tissues rely on the activity of stem cells to sustain their structure and proper functioning. These stem cells are responsible for generating various types of cells, that are essential for the tissue's normal homeostasis, ...
Oxidoreductase enzyme complexes are one of the known biomolecular machines, which play a crucial role in cellular biochemistry including metabolic, signaling, and electron transport pathways. In these complexes, individual subunits can...
The follicular epithelium (FE) of the Drosophila egg chamber is an excellent model system to study cell-cycle regulation, cell differentiation and cell migration in development. During oogenesis, follicle cells sequentially undergo three...
The temporal order in which segments of the genome are duplicated is referred to as the replication timing (RT) program. RT is established in each cell cycle coincident with the repositioning and anchorage of chromosomes in early G1. In...
Plants regulate gene expression at the transcriptional and post-transcriptional levels to produce a variety of functionally diverse cells and tissues that ensure normal growth, development, and environmental response. Although distinct...
Plants are often subjected to extreme environmental conditions and must adapt rapidly. The phytohormone abscisic acid (ABA) accumulates under abiotic stress conditions, signaling transcriptional changes that trigger physiological...
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus that has adapted unique mechanisms to modulate the cellular microenvironment of its human host. The pathogenesis of KSHV is intimately linked to its manipulation of...
Chromatin profiling in single cells has been extremely challenging and almost exclusively limited to histone proteins. In cases where single cell methods have shown promise, many require highly specialized equipment or cell type specific...
Controlling spatial-temporal gene expression patterns is a fundamental task for maize growth and development. With the emergence of massively parallel sequencing, genome-wide expression data production has reached an unprecedented level....
D4Z4 is a subtelomeric macrosatellite repeat on chromosome 4q that codes for DUX4, a gene that is causal to the muscle wasting disease Facioscapulohumeral muscular dystrophy (FSHD). DUX4 expression is influenced by a number of genetic...
During S-phase, the mammalian genome replicates in a defined temporal order called the DNA Replication Timing (RT) program. This program is developmentally regulated and is perturbed in diseased cell states, such as cancers and progeria....
Ecophysiology of Ectothermic Ecosystem Engineers: Bioenergetic Effects of Climate and Food on Dominant Consumers and Their Consequences for Coastal Ecosystems
This body of work explores dynamics of temperate marine grazers that are sensitive to food availability and inhabit regions with dramatic contemporary variation in abiotic conditions due to nearshore upwelling. Climate change projections...
DNA replication in all Eukaryotes follows a defined temporal order termed replication-timing program (RT), which is coupled with the spatial separation of chromatin distribution inside the nucleus. Early or late replicating chromatin...
XCI is a form of dosage compensation that is established in early development of female mammals where one X chromosome is randomly silenced, thus balancing expression of X-linked genes. XCI is achieved by many cis- and trans- elements...
Regular emergence and re-emergence of viral pathogens emphasizes the importance of understanding viral biogeography and migration. Single-stranded DNA (ssDNA) viruses are among the least understood groups of microbial pathogens, yet the...
Pathogenic microorganisms gain entry inside the host cell by breaching anatomical barriers andinvading tissues. The host cell in turn depends on the sentinels of cell autonomous defense system to fight off the invading pathogen. This...
Assimilatory NADPH-dependent sulfite reductase (SiR) is the enzyme responsible for the six-electron reduction of sulfite to sulfide. In Enterobacteria, SiR is a dodecameric complex with two subunits: an octameric flavin-containing SiRFP, ...
Chromatin remodelers alter DNA-histone interactions in eukaryotic organisms, and have been well characterized in yeast and Arabidopsis. While there are maize proteins with similar domains as known remodelers, the ability of the maize...
Flaviviruses are positive sense single-stranded enveloped RNA viruses, most are mosquito-transmitted viruses that cause systemic infection as they disseminate through the bloodstream in vertebrate hosts. The members of the flavivirus...
The cis-regulatory elements encoded by the genome and the epigenetic regulation that influences their function are necessary for defining organismal phenotype. However, a gap exists in our understanding of the role that epigenetic...
Zika virus is an arbovirus that has reemerged in recent years as a global health concern. A member of the Flavivirus genus, Zika virus is closely related to other major human pathogens such as dengue virus and West Nile virus, but each...
Cells sense and respond to topographical cues in their microenvironment that influence growth, development, and migration. Cell migration and outgrowth assays have been used to study cellular movement or changes in cellular morphology...
Animals can easily develop new food preferences and aversions through associative learning. If they consume a novel flavor and experience malaise, they develop an aversion towards that particular flavor, food or fluid. Conditioned taste...
Characterization of the Subcellular Localization of ORF52/KicGAS and Functional Roles during the Life Cycles of Kaposi's Sarcoma-Associated Herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that causes Kaposi's sarcoma (KS) and two lymphoproliferative diseases. We previously reported KSHV ORF52/KicGAS (KSHV inhibitor of cGAS) to inhibit cGAS (cyclic GMP...
Select silencing of gene expression in one X chromosome in female mammals provides a means to overcome X-linked gene expression imbalances with males. Central to establishing gene silencing on the inactivated X chromosome are the actions...
Understanding how a single genome can produce drastically different phenotypes is a central theme in evolutionary biology. It requires a keen understanding of the ecological, molecular, and genomic regulatory mechanisms driving...
Specific mutations in the replacement histone variant H3.3 are known to drive cancers such as glioblastomas, chondroblastomas and large cell tumors of the bone primarily in children and young adults. Several recent studies have suggested...
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