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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Heart related diseases have been the leading cause of death in the United States. Approximately 29% of patients die within 1 year after an initial stroke. Anticoagulants have been prescribed to prevent many thrombotic disorders to occur....
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to the lack of study materials, e.g., human...
Materials have significant impact on the advances of technology and development of civilization. For instance, the Stone Age, the Bronze Age, and the Iron Age are three historical periods identified by the materials people used. In more...
Polyethylenes with functional groups placed at precise locations along the backbone serve as model systems for studying the effect of co-units on crystallization behavior of polymers. Good thermal stability and high crystallinity...
Top-down fabrication is widely used for producing micro to nanometer scale features for biomedical applications. Opposed to bottom-up approach, it is superior to control geometry, structure and composition of the product. Traditional top...
Stroke is a leading causing of death and disability world-wide, and yet, few options for therapeutic treatment exist. Cell therapies, particularly human bone-marrow derived mesenchymal stem cells (hMSC), have elicited particular interest...
Cells sense the mechanical properties of their environment through physical engagement and spreading, with high stiffness driving nuclear translocation of the mechanosensitive transcription factor YAP. Restriction of cell spread area or...
Small intestinal submucosa (SIS) is an extracellular matrix (ECM) harvested from pig. It contains primarily collagen with multiple proteins and growth factors. It is a biocompatible scaffold that supports cell growth in vitro and can be...
Pulsed gas phase corona discharge was studied as a possible new technology for the removal of nitrogen oxides and volatile organic compounds from contaminated gases. The combination of pulsed positive streamer corona discharge with a...
A new future in automotive transportation is approaching where vehicles are powered by new, clean and efficient energy sources. While different technologies will contribute to this future, many see fuel cells as the leading long term...
The aim of this work is to develop a deeper understanding of the nuances involved in designing and optimizing the performance of gas/liquid plasma reactors for chemical synthesis. The design of such reactors requires integrating...
Extracellular vesicles (EVs) or exosomes are responsible for a variety of signaling processes and overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique...
Magnetic resonance electrical impedance tomography experiments were performed on the abdominal ganglia of aplysia californica at 11.75 T with matrix sizes of 64x64 and 128x128. The ganglia were suspended in a custom built circular...
Organic metal halide hybrids have recently emerged as a highly promising class of functional materials for a variety of optoelectronic applications. The exceptional structural tunability has been demonstrated for this class of materials...
Using the Layer by Layer (LbL) technique combined with microcontact printing, novel pH sensors were developed in order to detect the extracellular pH (pHe) of the cancerous cell lines K562 and HeLa. Key to this process was the...
Linear low density polyethylenes (LLDPEs are substantially linear polyethylenes [(C2H4)n]ย with randomly distributed 1-alkyl short chain branches. The presence of branches on the ethylene backbone sharply reduces the crystallinity level...
Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide novel tools for recapitulating the cytoarchitecture of human brain and for studying biological mechanisms of neurological disorders. However, the...
Designing an implantable construct requires the simulation of microenvironmental cues that drive cellular response in vivo. Guided bone regeneration (GBR) is a technique that utilizes a physical barrier membrane to facilitate healing of...
Isotactic poly(propylenes) (iPPs) are found to display profound melting kinetics at temperatures well below the apparent melting point. This unexpected behavior has not been observed earlier in semicrystalline polymers. This work...
ABSTRACT Precisely halogenated polyethylenes are unique polyolefins with a halogen placed on and every "n" number of backbone carbons. Contrasting random analogs, these systems are highly crystalline developing spherulitic morphologies...
Manipulation and transport of fluids in micro scale geometries in chemical and biological analysis is of great interest due to the inherent reduction in cost of fluid handling systems and reagents as well as the ease at which chemical...
Using a flow visualization technique in combination with rheology, we have studied five problemsthat pertain to particle motion in polymeric fluids: Effects of micellar relaxation spectrum and gradients in micellar extensions on flow...
The main product of this work is the detailed molecular structure of nanofibers formed by the RADA16-I designer peptide. RADA16-I is a designer self-assembling peptide that has shown great utility in the area of tissue engineering....
All-solid-state batteries are promising energy storage systems that improve safety by replacing the flammable and hazardous liquid electrolytes with chemically and structurally stable solid electrolytes. Polymer electrolytes are...
The objectives of this work are to determine the extent to which intracellular metabolite diffusion limits aerobic metabolism and hence dictates cellular dimensions and metabolic organization. The particular focus is on the reaction and...
Designer self-assembling peptides (small proteins) such as RADA16-I (1, 2, 7) and MAX8 (2) are being used as nanofiber scaffolds for supporting tissue regeneration. Specific applications of these materials in regenerative medicine...
Colloidal suspensions transform between fluid and disordered solid states when parameters such as the colloid volume fraction and the strength and nature of the colloidal interactions are varied. Seemingly subtle changes in the...
Copolymerization of propylene with 1, 9 decadiene using an isospecific metallocene catalyst leads to isotacic poly(propylenes) with H-type intermolecular linkages, resembling chemical crosslinks and leading to enhanced melt strength. In...
Over the last decade advanced oxidation reduction processes (AORP) have acquired significant importance in degrading minute concentrations (ppb to ppm levels) of recalcitrant contaminants that are difficult to degrade using conventional...
Intervertebral disc degeneration involves breakdown of the discs of the spine due to genetics, ageing or faulty mechanical loading. As part of the progression of the disease, nucleus pulposus cells lose their phenotypic characteristics, ...
Migraine is a disabling, multifactorial recurrent neurological disorder. Affecting approximately 38 million people in the United States alone, migraine is recognized by the World Health Organization as the 7th most disabling condition, ...
Scientists have used computers to model a plethora of systems since the rise of the computer age. The most common use of modeling is to analyze an existing system. With a complete model of an existing system the parameters can be changed...
Colloidal suspensions transform between fluid and disordered solid states when parameters such as the colloid volume fraction and the strength and nature of the colloidal interactions are varied. Seemingly subtle changes in the...
Microparticles are widely used and studied for biomedical applications and can be fabricated by bottom-up and top-down techniques. While the top-down techniques are superior to the bottom-up techniques in controlling particle geometry, ...
In this work, we study the dynamics of polyelectrolytes in microchannel and nanochannel flows under externally applied pressure and electric fields using both theoretical and computational approaches. Hydrodynamic interactions, acting...
Diffusion Tensor Imaging (DTI) provides a unique contrast based on the restricted directionality of water movement in an anisotropic environment. As such, DTI-based tractography can be used to characterize and quantify the structural...
This body of work explores the growth and structure of two different cobalt containing compounds that may show interesting quantum spin behaviors: [(CH3)3NH]CoCl3 and BaCo2(PO4)2. In [(CH3)3NH]CoCl3, the Co ions are arranged in a chain...
MRI magnets are constantly evolving with technologies for higher fields, improving sensitivity and increasing resolution. Major achievements in MRI magnet technology in recent years include the successful construction of a 21.1-T, 900...
Human mesenchymal stem cells (hMSCs) isolated from bone marrow have multi-lineage differentiation potential and have attracted considerable attention in bone tissue regeneration. However, previous studies have shown that 2D-expanded...
Ethylene 1-alkene copolymers with the same molar mass, same molar mass distribution and very similar average comonomer content of 3.8 +/- 0.4 mol% but different broad interchain comonomer content distribution (CCD), are found to display...
High field 1H and 23Na MRI provide sensitive metrics of quantifying ischemic stroke over time. In this work, the efficacy of human mesenchymal stem cells (hMSC) aggregated into 3D spheroids (a-hMSC) as a treatment method for ischemic...
Electro-osmotic flow, where an applied electric potential difference induces fluid motion, is extensively employed for fluid transport in microfluidic devices. In this thesis, we present a direct flow imaging method for characterizing...
The study of melt miscibility and structure-property relations of different types of polyolefins provide an important pathway to material design for different applications. In this work we study melt and crystalline properties of blends...
While neurodegenerative conditions represent a rapidly growing medical and social problem worldwide, the definite diagnosis of the most common neurodegenerative pathologies such as Parkinson's disease (PD), Progressive Supranuclear Palsy...
Lignin can be an important source of synthetic commodity materials owing to its abundance in nature and low production cost. The current main usage of lignin, however, is very limited to cheap and poorly defined nonfunctional materials, ...
Polymers are essential to modern life. Yet there still remains a wealth of knowledge to discover regarding novel polymeric materials, processing techniques, and applications. The synthesis and application of nanostructured amphiphilic...
Perfluorinated carbons are hazardous molecules that have contaminated ground water systems and become a prevalent environmental issue. One group of perfluorinated carbons is a class of molecules referred to as per- and polyfluoroalkyl...
Microfluidic devices are widely used for cell-based analysis. There are always needs to develop simpler, more effective and/or less costly devices than the existing ones for this application. A simple microfluidic device has been...
In the first part of this thesis, the bivariate or cross branching distribution of a film-grade ethylene 1-hexene copolymer with enhanced MD and TD Elmendorf tear (> 400 g/mil) and high dart impact, synthesized ExxonMobil Chemical...
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