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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Have you ever noticed when you are hungry and looking for something to eat, you can smell the freshly salted fries of McDonalds before seeing the golden arches? That is because our sense of smell, olfaction, is intimately linked with...
The role of insulin pathways in olfaction are of significant interest with the widespread pathology of Diabetes mellitus and its associated metabolic and neuronal co-morbidities. Previous experiments have been conducted examining insulin...
The voltage-gated potassium channel, Kv1.3, carries 60-80% outward current in the olfactory bulb (OB) primary output neuron, the mitral cell. Gene-targeted deletion of the Kv1.3, produces lean mice that have supernumerary and...
The metabolic state of an organism and their sense of olfaction are closely interrelated. There is significant evidence that olfactory signals can modulate multiple metabolic parameters and, in turn, that metabolically relevant signals...
Targeting the Kv1.3 Ion Channel with Peptide Inhibitors and Nanoparticle Bioconjugates: Neuromodulation of the Olfactory Bulb and Its Influence on Whole-Body Metabolism
Electrical signaling in the olfactory bulb (OB) is modulated by changes in metabolic state. The voltage-gated potassium channel, Kv1.3, makes up 60 - 80% of the outward current flow in mitral cells (MCs), the primary projection neurons...
Voltage-gated potassium ion channels such as Kv1.3 have a role in altering excitability of neurons. The neuron has to have a sophisticated mechanism to regulate the modulation, expression, turnover and distribution of ion channels. Ion...
Neuromodulation plays important roles in adjusting our nervous system to produce behaviors. The same neuromodulator could have different effects on different targets, or the same target could be modulated by multiple neuromodulators. In...
Olfactory perception affects the food choice of most living species. A strong set of data have been accumulated to demonstrate that the olfactory bulb, the first relay of olfactory information, as a metabolic sensor. Mitral cells of the...
Olfaction allows vertebrates to sense their chemical environment, and plays an important role in feeding behavior, reproduction, memory and learning. The first portion of the dissertation examined the signal transduction cascade in the...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
