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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Stroke is a leading causing of death and disability world-wide, and yet, few options for therapeutic treatment exist. Cell therapies, particularly human bone-marrow derived mesenchymal stem cells (hMSC), have elicited particular interest...
Extracellular vesicles (EVs) or exosomes are responsible for a variety of signaling processes and overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique...
Magnetic resonance electrical impedance tomography experiments were performed on the abdominal ganglia of aplysia californica at 11.75 T with matrix sizes of 64x64 and 128x128. The ganglia were suspended in a custom built circular...
Organic metal halide hybrids have recently emerged as a highly promising class of functional materials for a variety of optoelectronic applications. The exceptional structural tunability has been demonstrated for this class of materials...
Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide novel tools for recapitulating the cytoarchitecture of human brain and for studying biological mechanisms of neurological disorders. However, the...
Designing an implantable construct requires the simulation of microenvironmental cues that drive cellular response in vivo. Guided bone regeneration (GBR) is a technique that utilizes a physical barrier membrane to facilitate healing of...
The main product of this work is the detailed molecular structure of nanofibers formed by the RADA16-I designer peptide. RADA16-I is a designer self-assembling peptide that has shown great utility in the area of tissue engineering....
Designer self-assembling peptides (small proteins) such as RADA16-I (1, 2, 7) and MAX8 (2) are being used as nanofiber scaffolds for supporting tissue regeneration. Specific applications of these materials in regenerative medicine...
Migraine is a disabling, multifactorial recurrent neurological disorder. Affecting approximately 38 million people in the United States alone, migraine is recognized by the World Health Organization as the 7th most disabling condition, ...
In this work, we study the dynamics of polyelectrolytes in microchannel and nanochannel flows under externally applied pressure and electric fields using both theoretical and computational approaches. Hydrodynamic interactions, acting...
Diffusion Tensor Imaging (DTI) provides a unique contrast based on the restricted directionality of water movement in an anisotropic environment. As such, DTI-based tractography can be used to characterize and quantify the structural...
High field 1H and 23Na MRI provide sensitive metrics of quantifying ischemic stroke over time. In this work, the efficacy of human mesenchymal stem cells (hMSC) aggregated into 3D spheroids (a-hMSC) as a treatment method for ischemic...
While neurodegenerative conditions represent a rapidly growing medical and social problem worldwide, the definite diagnosis of the most common neurodegenerative pathologies such as Parkinson's disease (PD), Progressive Supranuclear Palsy...
Lignin can be an important source of synthetic commodity materials owing to its abundance in nature and low production cost. The current main usage of lignin, however, is very limited to cheap and poorly defined nonfunctional materials, ...
Diffusion tensor imaging (DTI) provides a map of diffusional anisotropy based on the Brownian motion of water within the restricted boundaries of tissues. In this work, a high angular resolution DTI acquired with 18 diffusion directions...
Nucleic acid delivery is crucial for several biomedical applications, including tissue engineering, medical implant coatings, cancer treatment and regenerative medicine. Localized delivery of nucleic acids through biomaterial substrates...
Migraine affects approximately 38 million people in the United States, and is the 8th most disabling condition in the world. Though several hypotheses implicate neuronal and trigeminovascular involvement with migraine onset and...
Roughly 800, 000 Americans a year suffer an ischemic stroke, motivating numerous clinical and preclinical research endeavors into therapeutic applications to mitigate degenerative affects. One of the more promising potential therapeutics...
Neurodegenerative diseases affect large portions of the population worldwide and account for a significant portion of medical spending in associated costs. This dissertation will attempt to utilize graph theory and Magnetic Resonance...
There are many safety concerns with cryogenic systems around the world such as particle accelerators. One large concern is the sudden loss of vacuum within the particle accelerator systems. Loss of vacuum can lead to catastrophic...
Magnetic resonance imaging (MRI) relaxation and diffusion properties are sensitive to the physiological state of cells and tissues. In particular, cerebral ischemia and stroke is associated with a reduced apparent diffusion coefficient ...
The issue of non-degradable petroleum-based plastics waste is a global challenge that requires urgent attention due to its harmful impact on humans and the environment. To overcome this challenge, biomass-based materials have received...
Single-walled carbon nanotubes (SWCNTs) thin films exhibit great potential in various applications thanks to their extraordinary physical and mechanical properties. However, to fully take advantage of their superior properties there are...
The fate of human mesenchyam stem cells (hMSCs) is determined in large part by microenvironmental cues. Cells respond to these biochemical and biophysical signals through proliferation, specific lineage commitment and differentiation, or...
An important recent issue of polymer synthesis is a green polymerization that uses water as a solvent due to sustainability and environmental concern. Desirable ligand design is important for a highly active homogeneous aqueous...
Human induced pluripotent stem cells (hiPSCs) are recognized as an excellent alternative to embryonic stem cells in the fields of regenerative medicine, in vitro model construction, and drug discovery. Given the challenge of limited...
Stem cells have been proven to be an essential part of the human body when it comes to growth, development, maintenance, and repair. Human induced pluripotent stem cells (hiPSCs) are programmed to behave and differentiate with the...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
