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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The sulfur-rich protein (SRP) in soybeans is a 7S basic globulin that accounts for up to 5% of the total extractable seed proteins. Sulfur-containing amino acids are the limiting amino acids in most food legumes and therefore there is a...
Cancer of the esophagus has a high mortality rate of greater than 82% within five years of diagnosis. There is little difference in mortality rate between the two main subtypes of esophageal cancer (EC), esophageal squamous cell cancer ...
The food matrices in the category of dairy, nuts, vegetables, legumes, cereal, cereal products, fruits and confectionery, salt, seeds, tea and color were analyzed for the matrix effect. Most of the food matrices under the category of...
The metabolic state of an organism and their sense of olfaction are closely interrelated. There is significant evidence that olfactory signals can modulate multiple metabolic parameters and, in turn, that metabolically relevant signals...
Both leptin (LEP) and amylin (AMN) are putative weight-reducing factors of clinical relevance to the treatment of obesity. First, we examined the possibility that chronic peripheral LEP infusion at physiological levels would inhibit food...
Chemical composition of 25 pecan varieties revealed considerable differences in moisture (2.1-6.4%), protein (6.0-11.3%), lipid (65.9-78.0%), total soluble sugars (3.3-5.3%), ash (1.2-1.8%) and tannins (0.7-2.7%) when analyzed on an...
Fish allergy is a worldwide problem, especially in industrialized countries where fish consumption is high. Fish contains a wide variety of proteins but, only few of them are responsible for triggering an allergic reaction. The major...
Voltage-gated potassium ion channels such as Kv1.3 have a role in altering excitability of neurons. The neuron has to have a sophisticated mechanism to regulate the modulation, expression, turnover and distribution of ion channels. Ion...
Cancer patients undergoing chemotherapy report changes in behavior commonly referred to as “chemo brain.” It is hypothesized that neuroinflammation contributes to the pathophysiology of “chemo-brain.” I examined the effects of naproxen, ...
There is a well-documented sexual dimorphism in the neural control of food intake and body weight regulation. Estradiol is a leading candidate as a potential biological factor contributing to these sex differences due to its robust...
Introduction: Cold-induced changes in lactate kinetics are critically important for athletes, particularly those training and competing in the cold. Alterations in lactate production and/or clearance may result in altered blood lactate...
I report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and gene expression in the amygdala, a brain region associated with the regulation of anxiety and fear responses. C57BL/6 mice consumed drinking water...
This dissertation discusses signal transduction cascades in the vomeronasal organ (VNO) of the stinkpot turtle, Sternotherus odoratus and the Sprague-Dawley rat by investigating downstream signaling events leading to a vomeronasal...
Yin Yang 1 (YY1) is a multifunctional transcription factor that can activate or repress transcription depending on the promotor and/or the co-factors recruited. YY1 is phosphorylated in various signaling pathways and is critical for...
Dendritic spines are small protrusions from dendrites on which the majority of excitatory synapses occur (Gray, 1959; Peters et al., 1976; Harris and Kater, 1994). Dendritic spines serve to compartmentalize second messenger systems (Koch...
Background: Undernutrition and anemia are comorbid conditions. The anemia associated with undernutrition is often attributed to increased rates of infection; however, iron deficiency is also common in areas where undernutrition is...
The trigeminal subnucleus caudalis (Vc), which has been designated as the "medullary dorsal horn"- analogous to the spinal dorsal horn (DH), relays noxious input from the orofacial region to higher brain centers. Recent work in our lab...
The zebra finch (Taeniopygia guttata) has long been used as an animal model for memory and cognition due to the naturally occurring process through which they acquire and produce song This process, in which song is learned from tutor...
Humans are largely dependent upon cone-mediated vision. However, death or dysfunction of rods, the predominant photoreceptor subtype, results in secondary loss of cones, remodeling of retinal circuitry, and blindness. The changes in...
Inhibition of hypothalamic TRH neurons is a well-established adaptation to caloric restriction that suppresses pituitary secretion of thyroid hormone, but may also participate in modulation of autonomic function. Central TRH, downstream...
We determined the influence of thermonuetrality on the oxygen consumption (VO2) and heart rate (HR) responses to short-term moderate fat feeding in male C57BL/6J (B6; obesity-prone) mice and A/J (obesity-resistant) mice. Mice were...
Background: Osteoporosis is a serious condition in which bone of the skeleton deteriorates substantially, resulting from an imbalance of the bone remodeling process. Affecting more than 40 million Americans, osteoporosis leads to major...
One of the core pathogenic mechanisms for schizophrenia is believed to be dysfunction in glutamatergic synaptic transmissions, particularly hypofunction of N-methyl D-aspartate receptors (NMDARs). In addition, previous genetic and...
The structure and function of the eye is conserved across vertebrates. Mutagenesis screens of zebrafish have led to the discovery of many genes essential for retinal development and function. In one such screen, a recessive allele on the...
Our DNA is under continuous stress by endogenous and exogenous attacks such as genotoxic chemicals, ionizing radiation, and metabolic products. DNA damage is extremely detrimental, even a single unrepaired damage is sufficient to kill a...
Breast cancer is the most prevalent form of cancer in women and accounts for 28% of all new cancer cases. Osteoporosis is another debilitating disease that affects approximately 10 million Americans. Postmenopausal breast cancer...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
