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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
The properties of proteins with reduced sequence complexity--either in the form of primary structure symmetry or restricted amino acid alphabets--are controversial. Studies of protein biophysics and sequence analyses suggest that...
Justification: Different porcine blood proteins have been widely used as emulsifier, binder and/or colorant in processed foods. However, misusage of porcine blood ingredients, such as mislabeling and substitution, can cause religious...
Structural biology has been successful in the characterization of soluble protein, which has given insight in the inner working of several thousands of proteins. However, structural characterization of proteins has been limited in two...
Solid-state NMR takes advantage of studying membrane proteins in a native membrane-like lipid bilayer and has been used for generating exciting results. The magic angle spinning ssNMR of randomly oriented liposomes provides complementary...
Most biomolecular NMR experiments rely on 1H detection because it offers high sensitivity, but 1H NMR experiments are limited by the chemical shift dispersion of 1H which presents significant challenges for accurate peak identification...
Human mesenchymal stem cells are a class of adult multipotent cells that are of interest to researchers for their clinical potential. While this cell type has been intensely investigated, there is still a significant amount to be learned...
Biogenesis of eukaryotic ribosomes is a complicated process that needs to be highly coordinated and tightly regulated. The small nucleolar ribonucleoprotein particles (snoRNPs) mediate the first step of ribosome biogenesis by carrying...
Collective protein structural transitions couple with fluctuations of their aqueous environment to enable biological function. Although decades of experiment have investigated protein-motion hy- dration couplings, atomistic details...
Major hallmarks of cancer include metastasis and evading the immune system. Despite cutting edge treatments developed in an era of extensive cancer research, immunotherapy has not been proven efficient enough in solid tumors, and...
The hexokinase family of enzymes catalyzes the ATP-dependent phosphorylation of glucose to generate glucose 6-phosphate and ADP. Consistent with highly evolved catalysts, hexokinases I-III possess high apparent substrate affinities (low...
Characterization of Protein Sequence Variants and Posttranlational Modifications by Top-down Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Histone variants and post-translational modifications (PTMs) are known to play central roles in genome regulation and maintenance. Quantitavely characterization of the variants and the associated PTMs is the first step to understand...
Protein function needs to get regulated in every organism, and mis-regulation of protein function can cause serious disease states. Regulation of protein function is essential for controlling and organizing many different cellular...
Mass spectrometry, featured at high sensitivity, is an indispensable tool in the field of biophysics for studying intact protein and protein complex. Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometer offers unparalleled...
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