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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to the lack of study materials, e.g., human...
Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide novel tools for recapitulating the cytoarchitecture of human brain and for studying biological mechanisms of neurological disorders. However, the...
Screening for effects of small molecules on cells grown in culture is a well-established method for drug discovery and testing, and faster throughput at lower cost is needed especially for lipophilic materials. Small-molecule arrays...
To improve the design of prostheses surfaces, our research group investigates how biocompatible polyelectrolyte multilayers (PEMUs) can be constructed to serve as coatings for biomedical implants, providing a versatile, inexpensive, and...
The objectives of this work are to determine the extent to which intracellular metabolite diffusion limits aerobic metabolism and hence dictates cellular dimensions and metabolic organization. The particular focus is on the reaction and...
Scientists have used computers to model a plethora of systems since the rise of the computer age. The most common use of modeling is to analyze an existing system. With a complete model of an existing system the parameters can be changed...
Microparticles are widely used and studied for biomedical applications and can be fabricated by bottom-up and top-down techniques. While the top-down techniques are superior to the bottom-up techniques in controlling particle geometry, ...
MRI magnets are constantly evolving with technologies for higher fields, improving sensitivity and increasing resolution. Major achievements in MRI magnet technology in recent years include the successful construction of a 21.1-T, 900...
While neurodegenerative conditions represent a rapidly growing medical and social problem worldwide, the definite diagnosis of the most common neurodegenerative pathologies such as Parkinson's disease (PD), Progressive Supranuclear Palsy...
Extensive research in the fields of biochemistry, biological sciences, genetics and molecular biology has helped scientists delve into the molecular machinery of cell function. However, the unity and common features of living organisms...
Skeletal muscle is responsible for the voluntary movement of materials through the body and locomotion; however, the performance and efficiency of the muscle depend on many factors including alterations in oxygen concentrations and...
MRI magnets are constantly evolving with technologies for higher fields, improving sensitivity and increasing resolution. Major achievements in MRI magnet technology in recent years include the successful construction of a 21.1-T, 900...
Gels are a very unique state of matter and play very important roles in nature. As a special intermediate state between solid and liquid, gels have some peculiar characteristics, such as phase transition and ion-exchange. These unique...
Tissue engineering is a rapidly developing field seeking to solve biomedical problems with wide-range of clinical applications. Major obstacles to the generation of functional tissue constructs in bioreactor culture devices for these...
Menopause leads to an increased risk for osteoporosis in women. Although drug therapies exist, increasing numbers of people prefer alternative therapies such as dietary supplements, e.g. calcium, vitamin D, and collagen hydrolysates for...
As fuel costs continue to increase, novel methods to produce energy are becoming very important. Methods to generate hydrogen from organic material for utilization in fuel cells have been the source of much research over recent decades....
Microparticles are widely used for biomedical applications. Top-down techniques are able to generate particles with non-spherical shapes, precisely defined geometries, and complex structures and compositions. These properties allow well...
Although diffusion is an important phenomenon for intra-cellular metabolite transfer, it is seldom considered while modeling cellular energetics. Weisz (1973) hypothesized that most biological and biochemical systems would most...
Quantification of the kinetics of liposome uptake by cells is a first step toward understanding the mechanism of uptake. It is also an essential prerequisite in the design of liposomes as drug carriers. The uptake of liposomes by cells...
Magnetic resonance imaging (MRI) relaxation and diffusion properties are sensitive to the physiological state of cells and tissues. In particular, cerebral ischemia and stroke is associated with a reduced apparent diffusion coefficient ...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
