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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
This dissertation focuses on microtubule assembly mechanisms and functions in dividing and non-dividing cells. In dividing cells, centrosome is the major microtubule-organizing center (MTOC). Ninein (Nin) is a centrosomal protein whose...
Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. ZIKV is part of the genus flavivirus, a class of positive(+)- sense single-stranded RNA viruses. Flavivirus...
A Tale of Two Drosophila Centrosome Proteins: The Regulation of Cilium Functions by Rootletin, and the Conversion of Sperm Mitochondria into Microtubule-Organizing Centers by CnnT
Using the fruit fly Drosophila melanogaster as a model organism, this dissertation dissects molecular and biological functions of three proteins: Rootletin (Root), testis-specific Centrosomin (CnnT) and Spermitin (Sprn). Centrosomes are...
Autosomal recessive primary microcephaly (MCPH, MIM 251200) is a neurodevelopmental disorder that results from a loss of neural progenitors in the embryonic neocortex. Patients with MCPH have a significantly small brain and exhibit...
The centrosome, comprised of a pair of centrioles, is the best-studied microtubule-organizing center (MTOC). However, after utilizing the centrosome to organize the mitotic spindle during cell division, differentiated cells will often...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
