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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Liver fibrosis is the common end stage of all chronic liver diseases, such as chronic viral hepatitis, alcoholism, nonalcoholic fatty liver disease, autoimmune hepatitis, alpha 1 anti-trypsin deficiency and some rare metabolic diseases....
Fibrosis is characterized by excessive synthesis of type I collagen which impedes the normal function of an affected organ. Type I collagen is the most abundant protein in the human body, produced by the folding of two a1(I) polypeptides...
LARP6 in Type I Collagen Expression and Embryonic Development: Role in Partition of Collagen mRNA to ER Membrane and in PIh1D3 Mediated Xenopus Development
Excessive production of Type I collagen is the hallmark of fibrotic disorders. The production of Type I collagen is mainly regulated at post-transcriptional level by a COLLAGEN mRNAs binding protein La ribonucleoprotein domain family...
The process of normal wound repair after tissue injury follows a closely regulated sequence involving inflammation, the recruitment, activation and proliferation of fibroblasts and the secretion of extracellular matrix, which culminates...
Characterization of Mechanisms Controlling Translational Regulation of Type I Collagen in Liver Fibrosis as Target for Novel Anti-Fibrotics and the Regulation of Neural Tube Closure during Embryonic Development
Pathological hepatic fibrosis represents a worldwide medical problem with substantial mortality and the number of cases is increasing. Despite all medical advances, effective therapy to treat progressive liver fibrosis is still...
The 5' stem-loop (5'SL) in the 5' UTR of collagen α1(I) and α2(I) mRNAs is the key element regulating stability and translation of collagen mRNAs. LARP6 is the RNA binding protein which exhibits high affinity binding to the 5'SL of...
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