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This dissertation presents the first single crystal 55Mn NMR characterization of three compounds related to Mn12-acetate [Mn12O12(O2CCH3)16(H2O)4]× 2CH3COOH-4H2O (henceforth Mn12-Ac) that have come to be known as Single-Molecule Magnets ...
This dissertation presents studies by magnetization, dc magnetic susceptibility and EPR spectroscopy on several new spin-frustrated polyoxometalate (POM) lattices of increasing spin sizes and complexities. Measurements have been made...
Solid-state carbon-13 nuclear magnetic resonance (NMR) spectroscopy has come to be considered the pre-eminent analytical technique for the study of soil organic matter in its entirety. Despite its widespread use, carbon-13 CP-MAS NMR of...
Block copolymer ionomers are a class of polymers that contain a hydrophobic block and a block containing charged repeat units. In the first set of experiments, micelles were created from such a polymer. A set of fluorescence probe...
This work describes the activation profiles and regulatory cascades of the human kallikrein-related peptidases. The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases, comprising 15 members (KLK1–15)...
Diphtheria toxin repressor is a regulatory protein from Corynebacterium diphtheriae, the causal agent of Diphtheria. The diphtheria toxin repressor (DtxR) contains an SH3-like domain that forms an intramolecular complex with a proline...
Small nucleolar RNAs (snoRNAs) are localized in the nucleolus as small ribonucleoprotein particle (snoRNP) that are RNA-protein complexes and catalyze site specific modifications on the ribosomal RNA. When compared to many protein...
Reproduced with permission from Journal of the American Chemical Society, submitted for publication. Unpublished work copyright 2008 American Chemical Society. The development of ternary nanoscale materials with controlled cross...
The properties of proteins with reduced sequence complexity--either in the form of primary structure symmetry or restricted amino acid alphabets--are controversial. Studies of protein biophysics and sequence analyses suggest that...
Metal flux synthesis was used to discover new Zintl phase materials and to grow crystals of superconducting phases. Reactions of barium and the pnictide elements Pn = P or As in indium melts produced new Zintl phases Ba2In5Pn5. This...
The impetus of this research was the synthesis and characterization of new Mg-based hydrogen storage materials. Synthetic methods included metal fluxes, distillations and traditional stoichiometric melts. Pure Mg or Mg-X (X=element other...
The highly interdisciplinary study of molecular magnetism spans a wide array of topics, ranging from spintronics and quantum computing to enzyme function and MRI contrast agents. At the core of all these fields is the study of materials...
The focus of this dissertation is the study of the magnetic properties of several novel lanthanide and actinide metal complexes, of particular concentration is the use of SQUID magnetochemistry coupled with electron paramagnetic...
Two independent topics are covered in this thesis. The first project covers the development of a new hydroxyl protecting group: para-siletanylbenzyl (PSB). The para-siletanylbenzyl (PSB) ether is electronically similar to the benzyl...
Molten metal fluxes are useful in materials synthesis. Dissolution in molten metal activates reactants at temperatures well below their melting point. Lower temperatures and the modified energetics in a flux increase the possibility of...
The work described in this thesis includes research done on two major projects, chemical heterogeneity and sequence length heterogeneities in copolymers. In the chemical heterogeneity project, we present a method by which to obtain the...
Nature presents active components in the form of proteins and molecular motors that are involved in locomotion and inter compartmental transport. Inspired by nature, this dissertation focuses on presenting experimental means to...
Radical Fragmentations: From Conformational Control of Enediyne Reactivity to 1,2-C,O Transposition and Metal-Free Synthesis of Benzoates and Benzamides from Phenols
The work described in this thesis is a demonstration of how theory and experiment can be used side by side in developing research in organic chemistry, from mechanistic studies to the design of new reactions. In chapter one we describe a...
This dissertation describes the synthesis and characterization of two new compounds that are among the most studied materials in solid state chemistry over the past eight or so years. The compounds investigated are [Mn12O12(CH3COO)16(H2O...
Advances in nonlinear optical spectroscopy have been employed to investigate interactions between nanostructures and electromagnetic energy. These efforts are directed toward the larger goal of optimizing the structure of photonic...
Removal of introns from pre-mRNA in eukaryotes is mediated by the spliceosome, a dynamic supramolecular complex comprising five small nuclear (sn)RNAs and numerous proteins, organized into small ribonucleoprotein (snRNP) particles. At...
The tunability of a material's structure is highly useful for designing a material with specific properties to meet current and future technological demands. This dissertation investigates the structure-property relationships of mixed...
The work in this dissertation presents methods developed for the measurement of small molecules in islets of Langerhans, including reactive oxygen species and amino acids. Reactive oxygen species were measured using fluorescence imaging....
Nonspecific interactions in biological media can lead to the formation of protein corona around nancolloids, which tend to alter their behavior and limit their utility when used as probes for imaging or sensing applications. Yet, ...
This dissertation is divided into two parts. In the first part, phosphorus sequestration in wetland soils is linked to carbon humification. The goal of the second part is to provide molecular-level characterization of biochars. The...
Liquid chromatography, particularly reversed-phase liquid chromatography (RPLC), is a ubiquitous analytical method throughout various industries. It has proven vital to the regulatory framework of agencies worldwide to ensure product...
Particle size, shape, and their distributions directly influence a variety of processing and end-use properties related to packing, mixing, and transport of powders, solutions, and suspensions. Many of the techniques currently employed...
Polyelectrolyte complexes (PECs) are made by mixing oppositely charged polymers. In this dissertation, a pair of pH-independent polyelectrolytes was used: a polycation, poly(diallyldimethylammonium), PDADMA, and a polyanion, poly...
This dissertation presents a survey of ab initio models developed based on the merger of multireference (MR) methods and density functional theory (DFT) in order to provide an accurate and efficient description of electron correlation...
This dissertation describes the characterization of magnetic sandwich-type transition metal substituted polyoxotungstates and large Fe3+ containing clusters with large total spins. A series of isostructural copper trimer polyanions, [Cu3...
Under normal physiological conditions, mature human coronary artery smooth muscle cells (hCASMCs) exhibit a 'contractile' phenotype marked by low rates of proliferation, migration, and protein synthesis, but these cells possess the...
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Instrumentation and Methods for Structural Characterization of Trapped Biomolecular Ions: Innovative MS/MS Techniques, Gas-Phase Hydrogen/ Deuterium Exchange, and Laser-Induced Fluorescence
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has become a powerful tool for biomolecular structural characterization because of its superior mass resolving power and high mass accuracy. Of particular interest...
This research discussed in this dissertation is comprised of three distinct projects. The first is the fabrication of carbon-silica nanocomposites from the pyrolysis of acrylonitrile in a porous Vycor® glass to form dispersed carbon...
The purpose of this thesis is to detail the study of the mechanochemical degradation of a semi-flexible, highly-extended polymer, in order to create a benchmark of quantitative data for use by future investigators interested in...
Polyelectrolyte multilayers are built by the alternating deposition of oppositely charged polymers from solutions onto a substrate. The physical and chemical properties of the multilayers can be controlled by the polyelectrolyte...
This dissertation reports on the synthesis of a new magnetic ferroelectric family of crystals, M3-x(NH4)xCr(O2)4 (M= K, Rb and Cs), and their characterization by variable temperature x-ray crystallography, specific heat, dielectric...
This dissertation presents the concept, development, and characterization of a new methodology for both qualitative and quantitative analysis of protein digests in solution. Two beam fluorescence cross correlation spectroscopy is used to...
In the United States, breast cancer is the most commonly diagnosed cancer in women, except for skin cancers. The American Cancer Society estimates there will be 268, 600 new cases in 2019 alone. It is also the second leading cause of...
This dissertation is focused on the study of a series of paramagnetic materials from molecular to nanoscale with increasing number of transition metal ions. We have successfully used techniques like SQUID magnetometry, high frequency...
Part I: Isocratic and Gradient Elution Reversed-Phase Liquid Chromatography for the Estimation of the Hydrophobicity Parameter Log K'W: Applications to Newer Generation Stationary Phases. Part II: Planar Electrochromatographic Instrumental Design and Results
The first half of this dissertation (Chapters 1-3) will discuss reversed-phase liquid chromatographic (RPLC) estimations of hydrophobicity. The RPLC retention values in purely aqueous mobile phases are used as measures of hydrophobicity....
Development and Application of the Variational Two-Electron Reduced Density Matrix Complete Active Space Self-Consistent Field Method to Address the Electron Correlation Problem in Quantum Chemistry
The goal of this dissertation is to describe a series of developments and applications of the variational two-electron reduced density matrix (v2RDM-) complete active space self-consistent field (CASSCF) method to the electron...
Human acidic fibroblast growth factor (FGF-1) is a member of the beta-trefoil superfold, a protein architecture that exhibits a characteristic threefold axis of structural symmetry. FGF-1 contains 11 beta-turns, the majority being type I...
This dissertation presents comprehensive NMR studies of three related hydrogen-bonded compounds ammonia borane (NH 3BH3), ammonium dihydrogen arsenate (NH4H2AsO4) and ammonium dihydrogen phosphate (NH4H2PO4). All these compounds were...
Optical Properties and Electronic Relaxation Dynamics of Monolayer-Protected Metal Clusters Studied Using Ultrafast Pump-Probe and Magneto-Optical Spectroscopies
This dissertation presents structure-specific descriptions of the optical properties and electronic relaxation dynamics of atomically monodisperse monolayer-protected gold clusters (MPCs). The relaxation dynamics of electronically...
In aqueous solution, solute conformational transitions are governed by intimate interplays of the fluctuations of solute–solute, solute–water, and water–water interactions. To more effectively sample conformational transitions in aqueous...
Over 232, 000 women will be diagnosed with breast cancer in 2014 in the United States, and approximately 40, 000 women will die from this disease. Similarly, it is estimated that 230, 000 men will be diagnosed with prostate cancer in the...
Copolymers comprise two different functionalities within one chain, arranged in different patterns according to the type of copolymer: Diblock, alternating, or random. The presence of these two different functionalities within the same...
Radical Fragmentations: From Conformational Control of Enediyne Reactivity to 1,2-C,O Transposition and Metal-Free Synthesis of Benzoates and Benzamides from Phenols
The work described in this thesis is a demonstration of how theory and experiment can be used side by side in developing research in organic chemistry, from mechanistic studies to the design of new reactions. In chapter one we describe a...
The successful growth of colloidal lead halide perovskite nanocrystals has generated tremendous interest in the community, due to the unique properties and the promise PQDs offer for use in applications involving light-emitting devices...
Three-dimensional reaction-diffusion systems are able to produce scroll waves which rotate around a curve called the filament. A scroll ring is formed when the filament is a closed curve. In isotropic systems where reactants have equal...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
