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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has been linked to severe neurological disorders such as microcephaly in newborns as well as Guillain-Barré syndrome in adults. It is closely related to other flaviviruses...
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) offer an adaptive immune system that protects bacteria and archaea from nucleic acid invaders through an RNA-mediated nucleic acid cleavage mechanism. Our knowledge of...
Extracellular vesicles (EVs) are membrane-encapsulated structures released by cells which carry signaling factors, proteins and microRNAs that mediate intercellular communication. Accumulating evidence supports an important role of EVs...
During the past 30 years, there have been several Flaviviridae threats. Among them, Hepatatis C virus (HCV) emerged in the Western hemisphere as the previously unidentified etiological agent of non-A non-B hepatitis in transfusion...
Epithelial tissues rely on the activity of stem cells to sustain their structure and proper functioning. These stem cells are responsible for generating various types of cells, that are essential for the tissue's normal homeostasis, ...
The current treatment for hepatitis C virus (HCV) consists of a combination therapy of alpha interferon (IFN-alpha) and ribivirin (RBV). Due to IFN resistance and side effects, new classes of drugs are needed to combat HCV infection....
Extracellular vesicles (EVs) are a heterogeneous population of membrane-bound nanoparticles that are essential mediators of cell-to-cell communication. They package diverse cargo that includes proteins, lipids, RNA, and DNA. EVs are...
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus of significant public health concern closely related to other highly pathogenic flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV). With the rise of ZIKV in...
Extracellular vesicles (EVs) are membrane enclosed vesicles released from cells that act as mediators of intercellular communication and are involved in normal physiological processes as well as pathological conditions. EVs can transfer...
The innate immune system acts as the first line of defense against invading pathogens throughrecognition of pathogen associated molecular patterns or danger associated molecular patterns. Several germline encoded receptors, known as the...
DNA replication in all Eukaryotes follows a defined temporal order termed replication-timing program (RT), which is coupled with the spatial separation of chromatin distribution inside the nucleus. Early or late replicating chromatin...
Hepatitis C virus (HCV) infection leads to acute and chronic liver disease for thousands of people every year. With the absence of an effective treatment method, new classes of anti-HCV therapies are needed. Cyclosporine (CsA) and its...
Flaviviruses are positive sense single-stranded enveloped RNA viruses, most are mosquito-transmitted viruses that cause systemic infection as they disseminate through the bloodstream in vertebrate hosts. The members of the flavivirus...
Zika virus is an arbovirus that has reemerged in recent years as a global health concern. A member of the Flavivirus genus, Zika virus is closely related to other major human pathogens such as dengue virus and West Nile virus, but each...
Cyclophilin A (CyPA) and its peptidyl-prolyl cis/trans isomerase (PPIase) activity plays an essential role in hepatitis C virus (HCV) replication. Mounting evidence indicate nonstructural protein 5A (NS5A) of HCV as the major target of...
Hepatitis C virus (HCV) has emerged as a major cause of human liver disease, with ~3% of the world population persistently infected with and more than one million new cases of infection reported annually. In most cases, HCV escapes the...
DNA replication in eukaryotic cells follows a temporal order that is consistent from cell cycle to cell cycle and is correlated with the spatial organization of DNA in the nucleus. This "replication-timing program" is conserved in...
Hepatitis C virus (HCV) is an enveloped RNA virus that often manifests into chronic infections of the liver, which represents a threat to human health due to the morbidity it presents within infected patients. The virus is especially...
The hepatitis C virus (HCV) is a serious health threat globally. Current therapies are not tolerated well, have a low response rate, and there is no available vaccine. New viral targets for drugs are urgently needed. The aim of this...
Short Hairpin RNAs Delivered by Lentiviral Vector Transduction Trigger RIG-I-Mediated IFN Activation and Isolation of HCV with Enhanced Kinetics and Viral Assembly
Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, ...
Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
