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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Background: Nighttime eating, particularly before bed, has received considerable media attention in recent years. The common thought was to avoid caloric intake post-dinner and pre-sleep due to worries of weight gain and a negative...
The neuroendocrine system presents a diversity of patterns in hormone secretion across a large range of temporal scales. These patterns of secretion are crucial to many aspects of animal survival and behavior. This offers a wealth of...
Prolactin is a fertility hormone produced and released by the anterior pituitary gland. Normal changes in prolactin levels influence fertility and these changes are carefully regulated by neuroendocrine cells in the hypothalamus....
No studies have addressed the question of whether metformin reduces development of diabetes among adolescents who are obese. Metformin treatment in adolescents who are obese can modestly reduce risk factors for type 2 diabetes, including...
Weight loss therapy consisting of 20 to 30 lifestyle-modification group visits is associated with modest (4–8 kg) weight loss. (SOR A, based on homogeneous randomized controlled trials [RCTs].) For patients who participate in group...
Recent research suggests that stress and reward insensitivity may interact to confer risk for Major Depressive Disorder (MDD). However, no study has yet examined stress and reward sensitivity, and their interaction, in the context of...
How Safe and Effective is Pramlintide in Improving Long-Term Glycemic Control and Weight Loss in Patients with Type 2 Diabetes Mellitus Receiving Insulin?
There is a well-documented sexual dimorphism in the neural control of food intake and body weight regulation. Estradiol is a leading candidate as a potential biological factor contributing to these sex differences due to its robust...
Pancreatic islet beta-cells play a vital role in regulating blood glucose levels by releasing insulin into the bloodstream. Insulin is released in pulses that parallel interacting beta-cell rhythms, including oscillatory glucose...
Compared with low-fat diets, carbohydrate-restricted diets (eg, Atkins) produce more weight loss in the short term (at 6 months but not at 1 year) and produce a greater reduction in glycosylated hemoglobin (HbA1C). (SOR A, based on a...
Objectives: Pharmacist-managed collaborative services in a family practice setting are described, and diabetes and hypertension outcomes are assessed. Methods: Pharmacist-managed clinics, pharmacotherapy consultations, and drug...
With the number of individuals diagnosed with type 2 diabetes on the rise, it has become more important to ensure these patients are effectively treated. The Centers for Disease Control and Prevention estimated that 8.3% of all Americans...
INTRODUCTION: Obesity is associated with increased cardiometabolic disease risk, although the vascular and metabolic features of obesity are often studied independently. Resistance to both insulin-mediated suppression of lipolysis and...
Hypogonadism contributes to limb skeletal muscle atrophy by increasing rates of muscle protein breakdown. Androgen depletion increases markers of the autophagy-mediated protein breakdown pathway that persist throughout the diurnal cycle....
Diabetes and depression are both highly prevalent within the U.S. and it is worrisome that these two conditions are related. Several meta-analyses and studies using qualitative, clinical, and nationally representative cross-sectional...
Patients with Bell's palsy have higher cure rates when treated with oral prednisolone within 72 hours of onset (SOR B, based on a single randomized controlled trial), but it is unclear what effect this therapy would have on patients with...
The endocrine system manages the body's organ function and growth in harmony with each other and the environment. This system is a network of glands that control themselves and other organs via hormones. Building a healthy hormone...
Small changes in the dosing of levothyroxine (±25 mcg) are associated with large changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations, but not with measurable changes in hypothyroid symptoms, well...
It is recommended that pregnant women with Graves' disease and thyroid-stimulating hormone (TSH) antibodies be treated with an antithyroid drug, whereas those without TSH antibodies should simply be observed. Radioiodine treatment with...
Objective: Poverty is a risk factor for obesity. Using homelessness as a marker for poverty, we examined the prevalence of obesity in Leon County, Florida's homeless population to determine their attitudes and perceptions towards the...
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