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Pleiotropy, constraint, and modularity in the evolution of life histories

Full Title:

Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.

Creator:

Description:

Multicellular organisms display an enormous range of life history (LH) strategies and present an evolutionary conundrum; despite strong natural selection, LH traits are characterized by high levels of genetic variation. To understand the...

Date:

2017-02-01

Format:

journal article, text

Collection:

Department of Biological Science

Identifiers:

FSU_pmch_27936291, 10.1111/nyas.13256, PMC5318229, 27936291

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_27936291

Repository ID:

fsu:639707

Genome-wide association study identifies 74 loci associated with educational attainment.

Full Title:

Genome-wide association study identifies 74 loci associated with educational attainment.

Creator:

Okbay, Aysu, Beauchamp, Jonathan P, Fontana, Mark Alan, Lee, James J, Pers, Tune H, Rietveld, Cornelius A, Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S Fleur W, Oskarsson, Sven, Pickrell, Joseph K, Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S, Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H, Pina Concas, Maria, Derringer, Jaime, Furlotte, Nicholas A, Galesloot, Tessel E, Girotto, Giorgia, Gupta, Richa, Hall, Leanne M, Harris, Sarah E, Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E, Kaasik, Kadri, Kalafati, Ioanna P, Karlsson, Robert, Kong, Augustine, Lahti, Jari, van der Lee, Sven J, deLeeuw, Christiaan, Lind, Penelope A, Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B, van der Most, Peter J, Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J, Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E, Shi, Jianxin, Smith, Albert V, Poot, Raymond A, St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z, Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E, Biino, Ginevra, Bønnelykke, Klaus, Boyle, Patricia A, Campbell, Harry, Cappuccio, Francesco P, Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M, Faul, Jessica D, Feitosa, Mary F, Forstner, Andreas J, Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V, Harris, Tamara B, Heath, Andrew C, Hocking, Lynne J, Holliday, Elizabeth G, Homuth, Georg, Horan, Michael A, Hottenga, Jouke-Jan, de Jager, Philip L, Joshi, Peter K, Jugessur, Astanand, Kaakinen, Marika A, Kähönen, Mika, Kanoni, Stavroula, Keltigangas-Järvinen, Liisa, Kiemeney, Lambertus A L M, Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T, Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J, Lebreton, Maël P, Levinson, Douglas F, Lichtenstein, Paul, Lichtner, Liewald, David C M, Loukola, Anu, Madden, Pamela A, Mägi, Reedik, Mäki-Opas, Tomi, Marioni, Riccardo E, Marques-Vidal, Pedro, Meddens, Gerardus A, McMahon, George, Meisinger, Christa, Meitinger, Thomas, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W, Myhre, Ronny, Nelson, Christopher P, Nyholt, Dale R, Ollier, William E R, Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L, Petrovic, Katja E, Porteous, David J, Räikkönen, Katri, Ring, Susan M, Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R, Sarin, Antti-Pekka, Schmidt, Helena, Scott, Rodney J, Smith, Blair H, Smith, Jennifer A, Staessen, Jan A, Steinhagen-Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D, Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, van Rooij, Frank J A, Venturini, Cristina, Vinkhuyzen, Anna A E, Völker, Uwe, Völzke, Henry, Vonk, Judith M, Vozzi, Diego, Waage, Johannes, Ware, Erin B, Willemsen, Gonneke, Attia, John R, Bennett, David A, Berger, Bertram, Lars, Bisgaard, Hans, Boomsma, Dorret I, Borecki, Ingrid B, Bültmann, Ute, Chabris, Christopher F, Cucca, Francesco, Cusi, Daniele, Deary, Ian J, Dedoussis, George V, van Duijn, Cornelia M, Eriksson, Johan G, Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V, Gieger, Christian, Grabe, Hans-Jörgen, Gratten, Jacob, Groenen, Patrick J F, Gudnason, Vilmundur, van der Harst, Pim, Hayward, Caroline, Hinds, Hoffmann, Wolfgang, Hyppönen, Elina, Iacono, William G, Jacobsson, Bo, Järvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L R, Lehtimäki, Terho, Lehrer, Steven F, Magnusson, Patrik K E, Martin, Nicholas G, McGue, Matt, Metspalu, Andres, Pendleton, Neil, Penninx, Brenda W J H, Perola, Markus, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Samani, Nilesh J, Schlessinger, David, Schmidt, Reinhold, Sørensen, Thorkild I A, Spector, Tim D, Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A Roy, Timpson, Nicholas J, Tiemeier, Henning, Tung, Joyce Y, Uitterlinden, André G, Vitart, Veronique, Vollenweider, Weir, David R, Wilson, James F, Wright, Alan F, Conley, Dalton C, Krueger, Robert F, Davey Smith, Hofman, Albert, Laibson, David I, Medland, Meyer, Michelle N, Yang, Jian, Johannesson, Magnus, Visscher, Peter M, Esko, Tõnu, Koellinger, Philipp D, Cesarini, Benjamin, Daniel J

Description:

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide...

Date:

2016-05-26

Format:

journal article, text

Collection:

Department of Geriatrics

Identifiers:

FSU_pmch_27225129, 10.1038/nature17671, PMC4883595, 27225129, nature17671

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_27225129

Repository ID:

fsu:623043

Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine.

Full Title:

Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine.

Creator:

Shi, Yanxia, Steppi, Albert, Cao, Ye, Wang, Jianan, He, Max M, Li, Liren, Zhang, Jinfeng

Description:

Asian Americans (AS) have significantly lower incidence and mortality rates of breast cancer than Caucasian Americans (CA). Although this racial disparity has been documented, the underlying pathogenetic factors explaining it are obscure...

Date:

2017-01-15

Format:

journal article, text

Collection:

Department of Statistics

Identifiers:

FSU_pmch_28069798, 10.1158/0008-5472.CAN-16-1959, PMC5243181, 28069798

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_28069798

Repository ID:

fsu:639737

Meta-analysis of Genome-Wide Association Studies for Extraversion

Full Title:

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

Creator:

van den Berg, Stéphanie M, de Moor, Marleen H M, Verweij, Karin J H, Krueger, Robert F, Luciano, Michelle, Arias Vasquez, Alejandro, Matteson, Lindsay K, Derringer, Jaime, Esko, Tõnu, Amin, Najaf, Gordon, Scott D, Hansell, Narelle K, Hart, Amy B, Seppälä, Ilkka, Huffman, Jennifer E, Konte, Bettina, Lahti, Jari, Lee, Minyoung, Miller, Mike, Nutile, Teresa, Tanaka, Toshiko, Teumer, Alexander, Viktorin, Wedenoja, Juho, Abdellaoui, Abdel, Abecasis, Goncalo R, Adkins, Daniel E, Agrawal, Arpana, Allik, Jüri, Appel, Katja, Bigdeli, Timothy B, Busonero, Fabio, Campbell, Harry, Costa, Paul T, Smith, George Davey, Davies, Gail, de Wit, Harriet, Ding, Jun, Engelhardt, Barbara E, Eriksson, Johan G, Fedko, Iryna O, Ferrucci, Luigi, Franke, Barbara, Giegling, Ina, Grucza, Richard, Hartmann, Annette M, Heath, Andrew C, Heinonen, Kati, Henders, Anjali K, Homuth, Georg, Hottenga, Jouke-Jan, Iacono, William G, Janzing, Joost, Jokela, Markus, Karlsson, Robert, Kemp, John P, Kirkpatrick, Matthew G, Latvala, Antti, Lehtimäki, Terho, Liewald, David C, Madden, Pamela A F, Magri, Chiara, Magnusson, Patrik K E, Marten, Jonathan, Maschio, Andrea, Mbarek, Hamdi, Medland, Sarah E, Mihailov, Evelin, Milaneschi, Yuri, Montgomery, Grant W, Nauck, Matthias, Nivard, Michel G, Ouwens, Klaasjan G, Palotie, Aarno, Pettersson, Erik, Polasek, Ozren, Qian, Yong, Pulkki-Råback, Laura, Raitakari, Olli T, Realo, Anu, Rose, Richard J, Ruggiero, Daniela, Schmidt, Carsten O, Slutske, Wendy S, Sorice, Rossella, Starr, John M, St Pourcain, Beate, Sutin, Angelina R, Timpson, Nicholas J, Trochet, Holly, Vermeulen, Sita, Vuoksimaa, Eero, Widen, Elisabeth, Wouda, Jasper, Wright, Margaret J, Zgaga, Lina, Porteous, David, Minelli, Alessandra, Palmer, Abraham A, Rujescu, Dan, Ciullo, Marina, Hayward, Caroline, Rudan, Igor, Metspalu, Andres, Kaprio, Jaakko, Deary, Ian J, Räikkönen, Katri, Wilson, James F, Keltikangas-Järvinen, Liisa, Bierut, Laura J, Hettema, Grabe, Hans J, Penninx, Brenda W J H, van Duijn, Cornelia M, Evans, David M, Schlessinger, Pedersen, Nancy L, Terracciano, Antonio, McGue, Matt, Martin, Nicholas G, Boomsma, Dorret I

Description:

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome...

Date:

2016-03-01

Format:

journal article, text

Collection:

Department of Behavioral Sciences and Social Medicine

Identifiers:

FSU_pmch_26362575, 10.1007/s10519-015-9735-5, PMC4751159, 26362575

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_26362575

Repository ID:

fsu:620366

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.

Full Title:

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.

Description:

Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide...

Date:

2016-08-25

Format:

journal article, text

Collection:

Department of Mathematics

Identifiers:

FSU_pmch_27560520, 10.1371/journal.pgen.1006149, PMC4999139, 27560520, PGENETICS-D-16-00511

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_27560520

Repository ID:

fsu:628964

Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.

Full Title:

Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.

Creator:

Cole, Joanne B, Manyama, Mange, Kimwaga, Emmanuel, Mathayo, Joshua, Larson, Jacinda R, Liberton, Denise K, Lukowiak, Ken, Ferrara, Tracey M, Riccardi, Sheri L, Li, Mao, Mio, Washington, Prochazkova, Michaela, Williams, Trevor, Li, Hong, Jones, Kenneth L, Klein, Ophir D, Santorico, Stephanie A, Hallgrimsson, Benedikt, Spritz, Richard A

Description:

The human face is a complex assemblage of highly variable yet clearly heritable anatomic structures that together make each of us unique, distinguishable, and recognizable. Relatively little is known about the genetic underpinnings of...

Date:

2016-08-25

Format:

journal article, text

Collection:

Department of Mathematics

Identifiers:

FSU_pmch_27560698, 10.1371/journal.pgen.1006174, PMC4999243, 27560698, PGENETICS-D-16-00752

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_27560698

Repository ID:

fsu:633765

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Full Title:

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Creator:

Okbay, Aysu, Baselmans, Bart M L, De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G, Fontana, Mark Alan, Meddens, S Fleur W, Linnér, Richard Karlsson, Rietveld, Cornelius A, Derringer, Jaime, Gratten, Jacob, Lee, James J, Liu, Jimmy Z, de Vlaming, Ronald, Ahluwalia, Tarunveer S, Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C, Furlotte, Nicholas A, Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R, Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W, Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J, Lind, Penelope A, Liu, Tian, Matteson, Lindsay, Mihailov, Evelin, Miller, Michael B, Minica, Camelia C, Nolte, Ilja M, Mook-Kanamori, Dennis, van der Most, Peter J, Oldmeadow, Christopher, Qian, Yong, Raitakari, Olli, Rawal, Rajesh, Realo, Anu, Rueedi, Rico, Schmidt, Börge, Smith, Albert V, Stergiakouli, Evie, Tanaka, Toshiko, Taylor, Kent, Thorleifsson, Gudmar, Wedenoja, Juho, Wellmann, Juergen, Westra, Harm-Jan, Willems, Sara M, Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Bergmann, Sven, Bjornsdottir, Gyda, Boyle, Patricia A, Cherney, Samantha, Cox, Simon R, Davies, Gail, Davis, Oliver S P, Ding, Jun, Direk, Nese, Eibich, Peter, Emeny, Rebecca T, Fatemifar, Ghazaleh, Faul, Jessica D, Ferrucci, Luigi, Forstner, Andreas J, Gieger, Christian, Gupta, Richa, Harris, Tamara B, Harris, Juliette M, Holliday, Elizabeth G, Hottenga, Jouke-Jan, De Jager, Philip L, Kaakinen, Marika A, Kajantie, Eero, Karhunen, Ville, Kolcic, Ivana, Kumari, Meena, Launer, Lenore J, Franke, Lude, Li-Gao, Ruifang, Liewald, David C, Koini, Marisa, Loukola, Marques-Vidal, Pedro, Montgomery, Grant W, Mosing, Miriam A, Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E, Pulkki-Råback, Laura, Quaye, Lydia, Räikkönen, Katri, Rudan, Igor, Scott, Rodney J, Smith, Jennifer A, Sutin, Angelina R, Trzaskowski, Maciej, Vinkhuyzen, Anna E, Yu, Lei, Zabaneh, Delilah, Attia, John R, Bennett, David A, Berger, Klaus, Bertram, Lars, Boomsma, Dorret I, Snieder, Harold, Chang, Shun-Chiao, Cucca, Francesco, Deary, Ian J, van Duijn, Cornelia M, Eriksson, Johan G, Bültmann, Ute, de Geus, Eco J C, Groenen, Patrick J F, Gudnason, Vilmundur, Hansen, Torben, Hartman, Catharine A, Haworth, Claire M A, Hayward, Caroline, Heath, Andrew C, Hinds, Hyppönen, Elina, Iacono, William G, Järvelin, Marjo-Riitta, Jöckel, Kaprio, Jaakko, Kardia, Sharon L R, Keltikangas-Järvinen, Liisa, Kraft, Kubzansky, Laura D, Lehtimäki, Terho, Magnusson, Patrik K E, Martin, Nicholas G, McGue, Matt, Metspalu, Andres, Mills, Melinda, de Mutsert, Renée, Oldehinkel, Albertine J, Pasterkamp, Gerard, Pedersen, Nancy L, Plomin, Polasek, Ozren, Power, Christine, Rich, Stephen S, Rosendaal, Frits R, den Ruijter, Hester M, Schlessinger, David, Schmidt, Helena, Svento, Rauli, Schmidt, Reinhold, Alizadeh, Behrooz Z, Sørensen, Thorkild I A, Spector, Tim D, Starr, John M, Stefansson, Kari, Steptoe, Terracciano, Antonio, Thorsteinsdottir, Unnur, Thurik, A Roy, Timpson, Nicholas J, Tiemeier, Henning, Uitterlinden, André G, Vollenweider, Wagner, Gert G, Weir, David R, Yang, Jian, Conley, Dalton C, Smith, George Davey, Hofman, Albert, Johannesson, Magnus, Laibson, David I, Medland, Sarah E, Meyer, Michelle N, Pickrell, Joseph K, Esko, Tõnu, Krueger, Robert F, Beauchamp, Jonathan P, Koellinger, Philipp D, Benjamin, Daniel J, Bartels, Meike, Cesarini

Description:

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits...

Date:

2016-06-01

Format:

journal article, text

Collection:

Department of Behavioral Sciences and Social Medicine

Identifiers:

FSU_pmch_27089181, 10.1038/ng.3552, PMC4884152, 27089181, ng.3552

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_27089181

Repository ID:

fsu:622817

Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system

Full Title:

Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations.

Creator:

Bick, Johanna, Naumova, Oksana, Hunter, Scott, Barbot, Baptiste, Lee, Maria, Luthar, Suniya S, Raefski, Adam, Grigorenko, Elena L

Description:

In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In...

Date:

2012-11-01

Format:

journal article, text

Collection:

Florida Learning Disability Research Center

Identifiers:

FSU_pmch_23062307, 10.1017/S0954579412000806, PMC3755948, 23062307, S0954579412000806

URLs:

http://purl.flvc.org/fsu/fd/FSU_pmch_23062307

Repository ID:

fsu:598504

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