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Some of the material in is restricted to members of the community. By logging in, you may be able to gain additional access to certain collections or items. If you have questions about access or logging in, please use the form on the Contact Page.
Heparin does not appear to improve overall outcomes when used for ischemic stroke or within the first 2 weeks of a cardioembolic stroke. (SOR B, extrapolated from meta-analyses of multiple heparinoids.)
Cefotaxime, ceftriaxone, and respiratory fluoroquinolones are recommended for influenza-associated pneumonia. Oseltamivir and zanamivir can be used to reduce viral shedding in hospitalized patients with influenza, with or without...
Patients using the leukotriene inhibitor montelukast require less frequent use of rescue medication than patients using the long-acting beta-agonist salmeterol. (SOR B, based on a single randomized controlled trial [RCT]). No studies...
The human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145W transgenic mice ...
Coenzyme Q10 (CoQ10) may lower systolic and diastolic blood pressures in patients with primary hypertension, but is not recommended as an antihypertensive treatment (SOR: C, systematic review of low-quality RCTs using disease-oriented...
A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based...
Current guidelines recommend that patients with acute asthma exacerbations be treated with systemic corticosteroids for 5 to 10 days, so continued steroid therapy is an option. However, limited evidence suggests that a 2-week course of...
Recommended first-line antibiotic therapy for community-acquired (CA) pneumonia is 5 days of a macrolide in adults and 3 to 5 days of amoxicillin in children. (SOR: C, based on consensus guidelines.) In otherwise healthy adults, there is...
Women who smoke, have hypertension, hyperlipidemia, or factor V Leiden deficiency and take oral contraception (OC) are at increased risk of myocardial infarction (MI). Third-generation OCs and low-dose OCs are not associated with...
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